PMID: 15379637Sep 24, 2004Paper

TSC-22 (TGF-beta stimulated clone-22): a novel molecular target for differentiation-inducing therapy in salivary gland cancer

Current Cancer Drug Targets
Hitoshi KawamataY Imai

Abstract

TSC-22 (Transforming growth factor-beta stimulated clone-22) was originally isolated as a TGF-beta-inducible gene in mouse osteoblastic cells. TSC-22 encodes a putative transcriptional regulator containing a leucine zipper-like structure. Several differentiation-inducing stimuli up-regulate the TSC-22 gene. Furthermore, TSC-22 acts as an effector that integrates multiple extracellular signals during embryogenesis of Drosophila and mouse. Separately, we identified TSC-22 cDNA as an anti-cancer drug (vesnarinone)-inducible gene in a human salivary gland cancer cell line, TYS. Vesnarinone is known to have a differentiation-inducing activity in several cell types. We showed that TSC-22 negatively regulated the growth of TYS cells, and that down-regulation of TSC-22 played a major role in the salivary gland tumorigenesis. Subsequently, we found that artificial overexpression of TSC-22 enhanced chemosensitivity and radiation-sensitivity by inducing apoptosis in TYS cells. Recently, we isolated TSC-22 genomic DNA and analyzed the transcriptional and post-transcriptional regulation of the TSC-22 gene. Then, we confirmed by the luciferase reporter assay that several differentiation-inducing stimuli directly activated the promoter region...Continue Reading

Citations

Apr 14, 2007·Journal of Mammary Gland Biology and Neoplasia·Torsten SteinBarry A Gusterson
Apr 28, 2009·Journal of Mammary Gland Biology and Neoplasia·Kathleen C Flanders, Lalage M Wakefield
Sep 21, 2013·Current Eye Research·John L BradleyRoderick J Fullard
May 17, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sonia CanteriniMaria Teresa Fiorenza
Oct 16, 2015·BMC Cardiovascular Disorders·Annina KelloniemiJaana Rysä
Oct 26, 2010·Biochimica Et Biophysica Acta·Liam PorttMichael T Greenwood
Dec 13, 2017·Oncotarget·Min-Ji ChoSeung-Hoon Lee
Apr 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiaodong WuLaurel A Raftery
Jul 28, 2016·Cold Spring Harbor Perspectives in Biology·Akiko Hata, Ye-Guang Chen

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