Tsetse flies, trypanosomes, humans and animals: what is proteomics revealing about their crosstalks?

Expert Review of Proteomics
Philippe HolzmullerD G Biron

Abstract

Human and animal African trypanosomoses, or sleeping sickness and Nagana, are neglected vector-borne parasitic diseases caused by protozoa belonging to the Trypanosoma genus. Advances in proteomics offer new tools to better understand host-vector-parasite crosstalks occurring during the complex parasitic developmental cycle, and to determine the outcome of both transmission and infection. In this review, we summarize proteomics studies performed on African trypanosomes and on the interactions with their vector and mammalian hosts. We discuss the contributions and pitfalls of using diverse proteomics tools, and argue about the interest of pathogenoproteomics, both to generate advances in basic research on the best knowledge and understanding of host-vector-pathogen interactions, and to lead to the concrete development of new tools to improve diagnosis and treatment management of trypanosomoses in the near future.

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Citations

Jul 14, 2012·Journal of Parasitology Research·Carolina Piña-VázquezJesús Serrano-Luna
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Feb 15, 2011·Journal of Proteomics·Anne GeigerPhilippe Holzmuller
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Oct 23, 2015·Metabolomics : Official Journal of the Metabolomic Society·Dong-Hyun KimMichael P Barrett

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African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.