Tsetse flies (Glossina spp.) are the prominent vector of African trypanosome parasites (Trypanosoma spp.) in sub-Saharan Africa, and Glossina pallidipes is the most widely distributed species in Kenya. This species displays strong resistance to infection by parasites, which are typically eliminated in the midgut shortly after acquisition from the mammalian host. Although extensive molecular information on immunity for the related species Glossina morsitans morsitans exists, similar information is scarce for G. pallidipes. To determine temporal transcriptional responses of G. pallidipes to Trypanosoma brucei brucei challenge, we conducted Illumina based RNA-seq on midgut organ and carcass from teneral females G. pallidipes at 24 and 48 h post-challenge (hpc) with T. b. brucei relative to their respective controls that received normal blood meals (without the parasite). We used a suite of bioinformatics tools to determine differentially expressed and enriched transcripts between and among tissues, and to identify expanded transcripts in G. pallidipes relative to their orthologs G. m. morsitans. Midgut transcripts induced at 24 hpc encoded proteins were associated with lipid remodelling, proteolysis, collagen metabolism, apoptosis...Continue Reading
Passage of Trypanosoma brucei rhodesiense through the peritrophic membrane of Glossina morsitans morsitans
Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma brucei.
The epidemiology of Trypanosoma rhodesiense sleeping sickness in Alego location, Central Nyanza, Kenya. I. Evidence that cattle may act as reservoir hosts of trypanosomes infective to man
Comparative study on the susceptibility of different laboratory strains of Glossina species to Trypanosoma simiae
The mosquito Anopheles stephensi limits malaria parasite development with inducible synthesis of nitric oxide
Dynamics of gene expression revealed by comparison of serial analysis of gene expression transcript profiles from yeast grown on two different carbon sources
Tsetse immune responses and trypanosome transmission: implications for the development of tsetse-based strategies to reduce trypanosomiasis
Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene
Immunopeptides in the defense reactions of Glossina morsitans to bacterial and Trypanosoma brucei brucei infections
The development of Trypanosoma brucei within the tsetse fly midgut observed using green fluorescent trypanosomes
SOME OBSERVATIONS ON THE RECENT EPIDEMIOLOGY OF SLEEPING SICKNESS IN NYANZA REGION, KENYA, AND ITS RELATION TO THE GENERAL EPIDEMIOLOGY OF GAMBIAN AND RHODESIAN SLEEPING SICKNESS IN AFRICA
Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts
Increased expression of unusual EP repeat-containing proteins in the midgut of the tsetse fly (Glossina) after bacterial challenge
Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research
Molecular characterization of a tsetse fly midgut proteolytic lectin that mediates differentiation of African trypanosomes
Innate immune responses regulate trypanosome parasite infection of the tsetse fly Glossina morsitans morsitans.
Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo
Response from Savioli and colleagues from the Department of Neglected Tropical Diseases, World Health Organization
Vector competence of Glossina palpalis gambiensis for Trypanosoma brucei s.l. and genetic diversity of the symbiont Sodalis glossinidius
Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes
The kinesin superfamily motor protein KIF4 is associated with immune cell activation in idiopathic inflammatory myopathies.
Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission.
Tripartite interactions between tsetse flies, Sodalis glossinidius and trypanosomes--an epidemiological approach in two historical human African trypanosomiasis foci in Cameroon
TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila.
Characterisation of the wildlife reservoir community for human and animal trypanosomiasis in the Luangwa Valley, Zambia.
Expansions of chemosensory gene orthologs among selected tsetse fly species and their expressions in Glossina morsitans morsitans tsetse fly.
Species-specific transcriptional profiles of the gut and gut microbiome of Ceratitis quilicii and Ceratitis rosa sensu stricto
African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.
Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis