TSH reference values in the first trimester of gestation and correlation between maternal TSH and obstetric and neonatal outcomes: a prospective Brazilian study

Archives of Endocrinology and Metabolism
Pedro Weslley RosarioMaria Regina Calsolari

Abstract

To define the normal range of TSH in the first trimester of gestation and to evaluate the correlation between maternal TSH and obstetric and neonatal outcomes. Prospective study. Women without known or clinically suspected thyroid disease and without risk factors for thyroid dysfunction, who became pregnant spontaneously and were initially evaluated up to week 12 of gestation, were included. Women with positive anti-thyroperoxidase antibodies, twin pregnancy, hyperemesis gravidarum, and trophoblastic disease were excluded. In the 660 pregnant women, the mean, median, and 2.5th and 97.5th percentiles of TSH were 0.9, 0.96, 0.04 and 2.68 mIU/L, respectively. TSH was undetectable in 2%, < 0.5 mIU/L in 17.4%, > 2 mIU/L in 9.7%, > 2.5 mIU/L in 4.7%, and > 3 mIU/L in 1%. None of the women received levothyroxine or antithyroid drugs during pregnancy. In addition, there was no difference in obstetric or neonatal outcomes when women with TSH ≤ 0.1, between 0.1 and 2.5, and between 2.5 and 4 mIU/L were compared. In the population studied, the TSH value corresponding to the 97.5th percentile was 2.68 mIU/L in the first trimester of gestation.

References

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Citations

Aug 18, 2016·Archives of Endocrinology and Metabolism·Léa Maria Zanini Maciel
Feb 6, 2018·Journal of Clinical Laboratory Analysis·Tomáš ŠálekJana Havalová
Jul 19, 2020·Journal of Clinical Medicine·Anna Karen Gárate-EscamillaAmir Hajjam El Hassani
Oct 12, 2018·Archives of Endocrinology and Metabolism·José Augusto Sgarbi
Nov 18, 2018·Thyroid : Official Journal of the American Thyroid Association·Allan Chen Dong, Alex Stagnaro-Green
Oct 12, 2018·Archives of Endocrinology and Metabolism·Nathalie Anne de Oliveira E Silva de MoraisPatrícia de Fátima Dos Santos Teixeira
Jan 28, 2022·Endocrine·Fausta BeneventiArsenio Spinillo

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