PMID: 2500700May 1, 1989Paper

TSH, thyroid hormones and nuclear-binding of T3 in mononuclear blood cells from obese and non-obese women

Scandinavian Journal of Clinical and Laboratory Investigation
L E MatzenK K Pedersen

Abstract

The specific nuclear-binding of T3 (NBT3) in mononuclear blood cells, and the concentrations of TSH, thyroid hormones, and binding proteins were measured after overnight fasting in 12 obese and in 14 non-obese women, none of the subjects were taking any medicine. The concentrations of TSH and free plus bound-T3 (TT3) were significantly higher in the obese (p less than 0.05), concentrations of T4 and binding proteins did not differ. The NBT3 was significantly lower in the obese women; the maximal binding capacity (MBC) was 34.5 +/- 11.6 fmol/mg DNA in the obese subjects and 50.0 +/- 11.6 fmol/mg DNA in the non-obese subjects (p less than 0.02). The binding affinities did not differ. We have previously shown that increasing T3 concentrations within the physiological range down-regulates NBT3. Therefore, the reduced NBT3 in the obese women was probably secondary to the increased TT3 concentration and was not caused by a primary tissue resistance. The higher TSH and TT3 in the obese women could be caused by a greater caloric intake.

Citations

Sep 19, 2003·European Journal of Internal Medicine·Jan Kvetny
Feb 21, 2006·Thyroid : Official Journal of the American Thyroid Association·Marina A MichalakiVenetsana E Kyriazopoulou
Nov 15, 2012·Journal of Clinical Research in Pediatric Endocrinology·Silvia Longhi, Giorgio Radetti
Aug 25, 2009·European Journal of Endocrinology·Maria AlevizakiKimon Stamatelopoulos
Jul 17, 2003·Clinical Endocrinology·Ramazan SariUmit Karayalcin
Dec 18, 2009·Acta Paediatrica·L WilmsJ Kvetny
Jul 8, 2015·Environmental Health Perspectives·Nancy A MervishUNKNOWN Breast Cancer and Environment Research Project (BCERP)
Oct 9, 2008·The Journal of Clinical Endocrinology and Metabolism·Giorgio RadettiMohamad Maghnie

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