TSLP Is a Potential Initiator of Collagen Synthesis and an Activator of CXCR4/SDF-1 Axis in Keloid Pathogenesis

The Journal of Investigative Dermatology
Jung U ShinKwang Hoon Lee

Abstract

Recently, thymic stromal lymphopoietin (TSLP), which is well studied in allergic diseases, has been reported in fibrotic diseases, including idiopathic pulmonary fibrosis and atopic dermatitis fibrosis. However, the role of TSLP in keloid is obscure. In this study, we assessed the expression of TSLP in keloid tissue and investigated the possible role of TSLP in keloid pathogenesis. We observed that TSLP expression was increased in keloid tissue compared to normal tissue. Furthermore, TSLP treatment induced increased collagen I and collagen III expression in fibroblasts via transforming growth factor-?; however, there was higher expression in keloid fibroblasts compared to normal fibroblasts. Stromal cell-derived factor-1?, which was recently reported to enhance wound healing through recruiting bone marrow-derived mesenchymal stem cells to the wound area, increased after TSLP treatment in fibroblasts and was primarily expressed in ?-smooth muscle action-positive myofibroblasts in keloid tissue. Furthermore, fibrocytes expressing CXCR4, a stromal cell-derived factor-1? receptor, were significantly increased in keloid tissue compared to normal tissue. Finally, intradermal TSLP injection on BALB/c mice increased stromal cell-derive...Continue Reading

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Citations

Jan 24, 2016·The Journal of Investigative Dermatology·Romy Beatriz Christmann
Nov 16, 2017·International Journal of Molecular Sciences·Chun Wook ParkHye One Kim
Aug 31, 2017·Nature Reviews. Immunology·Richard L GieseckThomas A Wynn
Apr 22, 2017·The Journal of Experimental Medicine·Lucia PattariniVassili Soumelis
Nov 1, 2017·American Journal of Respiratory Cell and Molecular Biology·Isabelle DupinPatrick Berger
Jun 13, 2020·Frontiers in Cell and Developmental Biology·Grace C LimandjajaSusan Gibbs
Jul 8, 2018·Science Immunology·Clare M Lloyd, Robert J Snelgrove
Nov 22, 2018·Frontiers in Immunology·Darrell Pilling, Richard H Gomer
Feb 6, 2021·Postgraduate Medical Journal·Ying-Yi LuChieh-Hsin Wu
Feb 1, 2021·The Journal of Allergy and Clinical Immunology·ZhengWang SunChang Ook Park
Jul 13, 2021·Frontiers in Immunology·Si-Hang Wang, Ya-Gang Zuo

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