TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells

Biochimica Et Biophysica Acta
Mariarosa RechichiLeonardo Rossi

Abstract

Gliomas are one of the most malignant cancers. The molecular bases regulating the onset of such tumors are still poorly understood. The translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, is a mitochondrial permeability transition (MPT)-pore protein robustly expressed in gliomas and involved in the regulation of apoptosis and cell proliferation. TSPO expression levels have been correlated with tumor malignancy. Here we describe the production of C6 rat glioma cells engineered to over-express the TSPO protein with the aim of providing the first direct evidence of a correlation between TSPO expression level and glioma cell aggressiveness. We observed that TSPO potentiates proliferation, motility and transmigration capabilities as well as the ability to overcome contact-induced cell growth inhibition of glioma cells. On the whole, these data demonstrate that TSPO density influences metastatic potential of glioma cells. Since several data suggest that TSPO ligands may act as chemotherapeutic agents, in this paper we also demonstrate that TSPO ligand-induced cell death is dependent on TSPO density. These findings suggest that the use of TSPO ligands as chemotherapeutic agents could be effectiv...Continue Reading

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C Braestrup, R F Squires
Aug 1, 1994·Molecular and Cellular Endocrinology·V PapadopoulosB Vidic
Apr 29, 1998·Annual Review of Physiology·G KroemerM Resche-Rigon
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·W XiaN L Spector
Feb 19, 2002·Neurochemistry International·Pierre CasellasAnthony S Basile
Aug 14, 2002·Current Medicinal Chemistry·Senyang Lang
Jan 28, 2003·Cancer Genetics and Cytogenetics·Matthew HardwickVassilios Papadopoulos
Jul 23, 2003·Current Medicinal Chemistry·Sylvaine GalieguePierre Casellas
Nov 25, 2003·Journal of Receptor and Signal Transduction Research·Zeqiu HanVassilios Papadopoulos
Mar 23, 2004·Annals of the New York Academy of Sciences·Florence VerrierCatherine Brenner
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sylvaine GaliègueJoelle Simony-Lafontaine

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Citations

Jul 3, 2010·Cancer Chemotherapy and Pharmacology·Germana RappaAurelio Lorico
Dec 22, 2015·Biochemical Pharmacology·Didier MorinBijan Ghaleh
Nov 26, 2013·Muscle & Nerve·Xiang ZhouXiaolin Liu
Jun 21, 2016·International Journal of Molecular Sciences·Valentino LaquintanaMassimo Franco
Jun 28, 2016·Journal of Biomedical Materials Research. Part a·Augustus T MercadoChung-Yung Chen
Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Eryn L WerryMichael Kassiou
Jan 20, 2017·Cell Cycle·Guo-Jun LiuRichard B Banati
Apr 12, 2018·International Journal of Molecular Sciences·Antonio LopalcoValentino Laquintana
Dec 2, 2010·Nature Reviews. Drug Discovery·Rainer RupprechtMichael Schumacher
Nov 10, 2015·Biochemical Society Transactions·Eryn L WerryMichael Kassiou
Apr 14, 2017·Neurotoxicity Research·Eliana BaezGeorge E Barreto
Aug 26, 2020·Cells·Benjamin B TournierPhilippe Millet
Jun 12, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Sara PiccinonnaGiovanni Natile
Oct 18, 2020·Cancers·Laura-Marie AmmerPeter Hau
Apr 4, 2021·International Journal of Molecular Sciences·Lorenzo GermelliBarbara Costa
Nov 12, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ali R AwdeAlexandra Winkeler
Jan 15, 2014·Molecular Pharmaceutics·Valentino LaquintanaMassimo Franco

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