TSPO regulation in reactive gliotic diseases

Journal of Neuroscience Research
Adam M McNeelaDustin J Hines

Abstract

The brain is the most metabolically active organ in the body. This high metabolic demand is apparent in that 60% of the brain is comprised of mitochondria-enriched cells. A disruption of the brain's ability to meet this immense metabolic demand is central to the pathogenesis of a multitude of neurological disorders, which range from depression to Alzheimer's disease. Central to these pathologies are glial signaling and energy metabolism cascades regulating apoptosis and inflammation. Thus, diseases causing inflammation and disruption of metabolism can be correlated with glial reactivity. Acutely, reactive gliosis provides a mechanism for limiting the progression of a disease. Following chronic activation, the ability of reactive gliosis to limit disease progression decreases and, in some cases, transitions into a harmful state. The necessity for a noninvasive biomarker of disease in the brain has linked reactive gliosis with an upregulation of translocator protein (TSPO). TSPO is an 18kDa protein that is both a therapeutic target for multiple acute and chronic neuroinflammatory diseases and the leading biomarker for Alzheimer's disease. Although a central function of TSPO is not well known, the protein was named for its ability...Continue Reading

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C Braestrup, R F Squires
Apr 1, 1994·Trends in Neurosciences·M K McMillianK R Pennypacker
Jul 1, 1994·American Journal of Respiratory Cell and Molecular Biology·J StolkA J Verhoeven
Aug 1, 1996·Trends in Neurosciences·G W Kreutzberg
Feb 22, 2001·Annual Review of Physiology·A AraqueP G Haydon
May 11, 2001·The New England Journal of Medicine·A I QureshiD F Hanley
Jun 8, 2001·Biochemical and Biophysical Research Communications·J J LacapèreB Vidic
May 27, 2004·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yann VerdierBotond Penke
Jun 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Simone Di GiovanniAlan I Faden
Jun 2, 2005·Journal of Neuroscience Research·Claudia Eder
Sep 10, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Michael V Sofroniew
Feb 14, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jens NeumannKlaus Dinkel
May 30, 2006·The Journal of Experimental Biology·Pierre J Magistretti
Sep 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Latha DeviHindupur K Anandatheerthavarada
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Cesare MancusoVittorio Calabrese
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Oct 30, 2007·Nature Neuroscience·Uwe-Karsten Hanisch, Helmut Kettenmann
Sep 16, 2008·Experimental Neurology·Jean F SoustielMoshe Gavish
Sep 29, 2009·Trends in Neurosciences·Michael V Sofroniew
Oct 27, 2009·Biochimica Et Biophysica Acta·Paula I MoreiraGeorge Perry
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jenna M Ziebell, Maria Cristina Morganti-Kossmann
Mar 12, 2010·Inflammatory Bowel Diseases·Mariano A OstuniJean-Jacques Lacapere
Jun 15, 2010·Structure·Vladimir M KorkhovChristopher G Tate
Jul 6, 2010·Molecular and Cellular Endocrinology·Amani Batarseh, Vassilios Papadopoulos
Nov 3, 2010·Psychoneuroendocrinology·Robert DantzerKeith W Kelley
Dec 3, 2010·Nature·Rongbin ZhouJürg Tschopp
Dec 15, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David R J OwenChristine A Parker
Apr 19, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alana M Scarf, Michael Kassiou
Jun 29, 2011·Annals of Neurology·Anil F RamlackhansinghDavid J Sharp

❮ Previous
Next ❯

Citations

Aug 21, 2018·Schizophrenia Bulletin·Allyson P Mallya, Ariel Y Deutch
Jan 7, 2020·Journal of Neuroinflammation·Vijayasree V GiridharanTatiana Barichello

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Journal of Neuroimmunology
Anna Członkowska, Iwona Kurkowska-Jastrzębska
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Alana M Scarf, Michael Kassiou
Neuroscience and Biobehavioral Reviews
Tatiana BarichelloJoao Quevedo
© 2022 Meta ULC. All rights reserved