PMID: 9161721May 1, 1997Paper

TsTX-VII, a new toxin from Tityus serrulatus scorpion venom able to induce the release of neurotransmitters from rat brain synaptosomes not blocked by tetrodotoxin

Biochemistry and Molecular Biology International
Suely Vilela SampaioJosé Roberto Giglio

Abstract

A procedure for the isolation of the toxin Tityustoxin VII (TsTX-VII) from Tityus serrulatus scorpion venom and its biochemical characterization is reported. This protein has a M(r) = 6,700-6,800, eight half-cystine residues accounting for four disulfide bridges and no His. Its N-terminal sequence GHZGYGS ... characterizes it as a new toxin, able to release glutamic acid and gamma aminobutyric acid from rat brain synaptosomes "in vitro". This release was also induced by the whole venom. Tetrodotoxin however blocked the effect of the whole venom but not that of TsTX-VII, thus suggesting that the releasing mechanism by TsTX-VII does not involve Na+ but perhaps K+ or Ca++ channels.

Citations

Feb 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Nuhan Purali
May 15, 2007·Brain Research Bulletin·Maria Alice da Cruz-HöflingCatarina Rapôso
Nov 3, 2015·Toxicon : Official Journal of the International Society on Toxinology·Manuela Berto PuccaGuilherme Honda de Oliveira
Oct 20, 2006·Toxicology and Applied Pharmacology·Alessandra L CecchiniEliane Candiani Arantes

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