TTB Protects Astrocytes Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury via Activation of Nrf2/HO-1 Signaling Pathway

Frontiers in Pharmacology
Liang LiuXiaolu Zhang

Abstract

Neonatal hypoxic/ischemic encephalopathy (NHIE) is a severe condition that leads to death or neurological disability in newborns. The underlying pathological mechanisms are unclear, and developing the target neuroprotective strategies are urgent. 2,7,2'-trihydroxy-4,4'7'-trimethoxy-1,1'-biphenanthrene (TTB) is a natural product isolated from Cremastra appendiculata (D. Don) Makino and Liparis nervosa (Thunb.) Lindl. TTB has demonstrated potent cytotoxic activity against stomach (HGC-27) and colon (HT-29) cancer cell lines. However, none of the studies have addressed the effects of TTB in NHIE. In the present study, an oxygen-glucose deprivation/reoxygenation (OGD/R)-induced astrocyte injury model was established to investigate the effect of TTB and its potential mechanisms. Our results showed that TTB alleviated the OGD/R-induced reactive oxygen species increase and the intracellular antioxidant capacity of superoxide dismutase activity decrease. Moreover, TTB potentially prolonged the activation state of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway and maintained the protection against oxidative stress in OGD/R-induced astrocytes by inducing the nuclear translocation and up-regulation ...Continue Reading

References

Jan 1, 1995·Annual Review of Biochemistry·I Fridovich
Mar 10, 1999·Methods : a Companion to Methods in Enzymology·L HertzJ C Lai
Oct 29, 2000·Journal of Applied Physiology·J C ChávezJ C LaManna
Feb 7, 2001·Science·E M UllianB A Barres
Dec 6, 2001·Journal of Child Neurology·M E DilengeM I Shevell
May 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert A NordalC Shun Wong
Jun 24, 2006·Journal of Natural Products·Zhen XueLan He
Sep 14, 2006·Annual Review of Pharmacology and Toxicology·Thomas W KenslerShyam Biswal
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·Karin B Nelson
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John D CahoyBen A Barres
Feb 22, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Grace VangeisonDavid A Rempe
Mar 14, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yachen LiLijia An
Jul 11, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicole Schmid-BrunclikOmolara O Ogunshola
Oct 24, 2009·Molecular and Cellular Neurosciences·Ethan G HughesRita J Balice-Gordon
Dec 1, 2009·Clinics in Perinatology·Ali FatemiMichael V Johnston
Jun 18, 2010·Early Human Development·Jennifer J KurinczukNadia Badawi
Nov 12, 2010·Nature·Cagla Eroglu, Ben A Barres
Apr 4, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ya-Yun HsuYi-Ching Lo
Jun 21, 2012·Journal of Neuroscience Research·Yihui MaDirk M Hermann
Nov 23, 2013·Neuropharmacology·Mats SandbergCarina Mallard
Jan 1, 2011·Therapeutic Hypothermia and Temperature Management·Sarah B MulkeyVivien L Yap
Oct 28, 2014·Current Pharmaceutical Design·Teresa ZalewskaMalgorzata Ziemka-Nalecz
Nov 27, 2014·Frontiers in Pediatrics·Marina GuizzettiDavid P Gavin
Nov 29, 2014·Methods in Molecular Biology·Carla I TascaHelena Cimarosti
Aug 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liang LiuPeng-Fei Tu
Dec 5, 2017·Experimental and Therapeutic Medicine·Shumei CaoQiaohong Hei
Dec 8, 2017·Biomolecules & Therapeutics·Byung-Jin JungSang-Min Jeon

❮ Previous
Next ❯

Citations

Oct 24, 2019·Mitochondrial DNA. Part B, Resources·Xujun WangQidong Liang
Mar 6, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Edward J Calabrese, Walter J Kozumbo

❮ Previous
Next ❯

Methods Mentioned

BETA
column chromatography
electrophoresis
Polymerase Chain Reaction
PCR
Nuclear Translocation
ubiquitination

Software Mentioned

Prism
GraphPad
ImageJ

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.