TU-E-217BCD-07: Pilot Study on Consistency in Size Metrics for a Multimodality PEM/MR Breast Imaging Approach

Medical Physics
M SadinskiH Li

Abstract

In this study, we evaluated the degree of consistency between size metrics obtained from PEM and MRI to determine the intrinsic effectiveness of a multimodality approach using these two systems for breast imaging. Under an IRB-approved protocol, 42 cases were considered (16 patients with 28 lesions), each consisting of an MRI data set and corresponding PEM data set, with an inclusion criterion of being obtained within 2 weeks of each other. Lesions were delineated manually on the PEM images and semi-automatically on the MRI images for efficiency. In addition to volume, equivalent sphere diameter (ESD) was evaluated for each lesion. This metric describes the diameter of a sphere with the same volume as that of the lesion, and is useful for minimizing the cubic impact of a single voxel contribution inherent to volume calculations. The relationship between PEM based volumes and MRI based volumes showed a linear trend around VolMRI=VolPEM demonstrating a degree of consistency in the two volumes. The correlation between VolMRI and VolPEM was calculated as 0.547 with a corresponding p-value of 0.00018 demonstrating a significant correlation. The associated concordance was calculated as 0.534. The ESD metric showed a more significant ...Continue Reading

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