TU-E-BRA-08: A Comprehensive Study on the Relationship between Image Quality and Imaging Dose in Low-Dose Cone Beam CT

Medical Physics
H YanSteve B Jiang

Abstract

To investigate image quality as a function of number of projections and tube load per projection in compressive sensing (CS) based low-dose cone beam CT (CBCT), and achieve optimal low-dose scan protocols in image guided radiation therapy (IGRT). We have performed CS-based CBCT reconstruction with different combinations of number of projections (from 46 to 364) and mAs (from 0.2 to 2.4 mAs/view), which covers the whole clinically relevant range. Image quality is assessed in each case. On this basis, optimal scan protocols are analyzed according to various IGRT applications. Image quality degrades ∼10% when the imaging dose decreases from 400 to 100 total mAs, further ∼10% from 100 to 40 total mAs, and another ∼80% below 40 total mAs. Image quality on iso-low-dose lines at 36.8, 72.6, 109.2 and 145.6 total mAs varies 17.16%, 13.69%, 11.99% and 5.74% in terms RMSE with various scanning protocols. 1) In CS-based CBCT, image quality has little degradation with imaging dose> 100 total mAs. Optimal low-dose scan protocols likely fall in the range of 40-100 total mAs. 2) At a constant low-dose level, the scan protocol that with super sparse views (projection number < 50) is the most challenging case. 3) The optimal scan protocol is th...Continue Reading

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