TU-E-BRB-03: Biological Dose Optimization for SBRT of Lung Cancer: One Size Does Not Fit All

Medical Physics
D ChenI Chetty

Abstract

Given the differences in tumor size and location, encountered in lung SBRT, we hypothesize that 'one dose fractionation regimen does not fit all', i.e. that there is a role for patient-specific dose prescription based on optimization of biological models. Sixty one NSCLC patients (tumor volume 46.5+/-47.3 cc) treated with stereotactic body radiotherapy (48 Gy in 4fx) were retrospectively studied. Clinically treated plans were generated using Brainlab's Pencil Beam (PB-BL), and then recalculated with fixed MUs using Anisotropic Analytic Algorithm (AAA), Pencil Beam (PB-EC), Monte Carlo (MC) and Collapsed-Cone-Convolution (CCC). DVHs were exported to calculate TCP (Poisson) and NTCP (Lyman-Kutcher-Burman). TCP/NTCP model parameters were utilized from published data. For each dose distribution two dose response curves were generated by scaling the prescription dose and assuming a linear relationship between the prescription dose and entire 3D dose distribution. In addition, associations were assessed between changes in each algorithm's TCP relative to PB-BL, target diameter, and local density (density of the 70% isodose covering the PTV). For PB-BL, mean TCP was 99.6%±0.9%, whereas for same MUs, mean TCP for PB-EC, AAA, CC and MC ...Continue Reading

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