PMID: 9535499Apr 16, 1998Paper

TU wave area-derived measures of repolarization dispersion in the long QT syndrome

Journal of Electrocardiology
W ZarebaJ Konecki

Abstract

The purpose of this study was to evaluate area-derived parameters of repolarization dispersion in LQTS patients and their unaffected family members and to use this analysis to challenge the concept of dispersion of repolarization in surface ECG. The area under the curve between the J point and the next P wave was measured automatically in 12 leads of the digital ECG in 34 LQTS patients and 22 unaffected family members. The area-derived measures of repolarization included total repolarization area, T wave amplitude, time to accumulate the first (tA50) and the median (tA25-75) 50% of the total area, and the time to accumulate 97% of the total repolarization area (tA97). In comparison with unaffected family members, LQTS patients had significantly higher dispersion of tA50 (tA50-SD = 34 +/- 18 ms vs 11 +/- 6 ms, respectively, P < .001) and tA25-75 (t[A25-75]-SD = 44 +/- 19 ms vs 24 +/- 15 ms, respectively, P < .001), whereas no significant difference was observed in the dispersion of total repolarization area, T wave amplitude, and time to accumulate total repolarization area (tA97-SD = 44 +/- 20 ms vs 53 +/- 19 ms, respectively, ns). It is concluded the analysis of area-derived parameters of repolarization showed that LQTS patien...Continue Reading

Associated Clinical Trials

References

Aug 1, 1990·Circulation·J BenhorinL Cui
Jun 1, 1990·British Heart Journal·C P DayR W Campbell
Dec 1, 1988·Circulation·J A VassalloM E Josephson
Apr 1, 1984·Journal of Electrocardiology·J C SylvénT J Montague
May 1, 1994·Pacing and Clinical Electrophysiology : PACE·J KautznerM Malik
Jan 1, 1995·Journal of Electrocardiology·W Zareba, A J Moss

❮ Previous
Next ❯

Citations

Jan 5, 2001·Pacing and Clinical Electrophysiology : PACE·A GhuranM Malik
Jan 15, 2000·Journal of Cardiovascular Electrophysiology·D M Roden, P M Spooner
Oct 18, 2006·Clinical Physiology and Functional Imaging·Milos KesekAnders Englund
Sep 11, 2009·Journal of Electrocardiology·Christian HaarmarkJørgen K Kanters

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.