Tualang Honey Protects against BPA-Induced Morphological Abnormalities and Disruption of ERα, ERβ, and C3 mRNA and Protein Expressions in the Uterus of Rats

Evidence-based Complementary and Alternative Medicine : ECAM
Siti Sarah Mohamad ZaidShatrah Othman

Abstract

Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that can disrupt the normal functions of the reproductive system. The objective of the study is to investigate the potential protective effects of Tualang honey against BPA-induced uterine toxicity in pubertal rats. The rats were administered with BPA by oral gavage over a period of six weeks. Uterine toxicity in BPA-exposed rats was determined by the degree of the morphological abnormalities, increased lipid peroxidation, and dysregulated expression and distribution of ERα, ERβ, and C3 as compared to the control rats. Concurrent treatment of rats with BPA and Tualang honey significantly improved the uterine morphological abnormalities, reduced lipid peroxidation, and normalized ERα, ERβ, and C3 expressions and distribution. There were no abnormal changes observed in rats treated with Tualang honey alone, comparable with the control rats. In conclusion, Tualang honey has potential roles in protecting the uterus from BPA-induced toxicity, possibly accounted for by its phytochemical properties.

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Citations

Jul 2, 2020·Journal of Biochemical and Molecular Toxicology·Chittaranjan SahuGopabandhu Jena
Jun 28, 2018·Environmental Science and Pollution Research International·Shuang MaXiuhui Zhong
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siti Sarah Mohamad ZaidMohd Helmy Mokhtar

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Methods Mentioned

BETA
light microscopy
MDA
electrophoresis
PCR
Assay

Software Mentioned

Statistical Package for Social Sciences ( SPSS
Biosystems
Applied

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