Tubal factor infertility with prior ectopic pregnancy: a double whammy? A retrospective cohort study of 2,892 women.

Fertility and Sterility
He CaiJuanzi Shi

Abstract

To investigate the impact of a history of previous naturally conceived tubal ectopic pregnancy (TEP) on subsequent IVF/intracytoplasmic sperm injection (ICSI) pregnancy and perinatal outcomes. Retrospective cohort study. Reproductive medicine center in a tertiary hospital. A total of 2,892 women with tubal infertility undergoing the first fresh IVF/ICSI cycle. Women were stratified into three groups according to the type of previous naturally conceived pregnancy: TEP, intrauterine pregnancy (IUP), and no pregnancy. Pregnancy and neonatal outcomes were analyzed for each cohort and stratified into the following categories based on female age: <30 years, 30-35 years, and ≥35 years. Of the 2,892 patients with tubal factor infertility, 511 (17.7%) women had a history of TEP, 1,044 (36.1%) had prior IUP, and 1,337 (46.2%) had never been pregnant. Couples with an initial TEP tended to be younger and had experienced a shorter duration of infertility. Across the whole cohort, the optimal live birth rate decreased in older age groups. Live birth rates stratified by maternal age (<30, 30-35, ≥35 years) did not differ between the TEP group (59.9%, 53.7%, 45.5%) and the IUP (62.0%, 53.8%, 40.6%) and no pregnancy group (56.7%, 54.4%, 45.6%)....Continue Reading

Citations

Jan 29, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Tingfeng FangWenjun Wang
Sep 11, 2020·Journal of Minimally Invasive Gynecology·Julian A GingoldTommaso Falcone
Apr 30, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ferruh AcetErol Tavmergen

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