Tubal Ligation Induces Quiescence in the Epithelia of the Fallopian Tube Fimbria

Reproductive Sciences
Ekaterina TiourinSanaz Memarzadeh

Abstract

Tubal ligation keeps the fimbriated end of the fallopian tube intact while interrupting the conduit for sperm and egg between the uterus and ovary. Tubal ligation is associated with an approximately 20% decreased risk of high-grade serous ovarian cancers, which mounting evidence suggests arise from the distal fallopian tube epithelium. We postulated that biological changes at the epithelial cellular level of the distal fallopian tube may account for the surgical procedure's observed risk reduction. We compared the histology, presence of epithelial progenitors (basally located CD44-positive cells), and degree of epithelial proliferation (Ki67-positive cells) of distal fallopian tube from 10 patients with previous tubal ligation and 10 age-matched patients with uncut fallopian tubes. A significantly reduced population of proliferating epithelial progenitors (basally located CD44/Ki67 dual-positive cells) was detected in the tubal ligated specimens (P = .0002). To functionally assess the effect of tubal ligation, a murine model was utilized to compare the growth capacity of distal fallopian tube epithelial cells isolated from either ligated or sham-operated tubal epithelia. Murine fallopian tube epithelial cells isolated after tub...Continue Reading

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Citations

Jun 15, 2017·American Journal of Obstetrics and Gynecology·Carmen GanRanjit Manchanda

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Methods Mentioned

BETA
contraception
hormone replacement therapy
transgenic
Assay

Software Mentioned

Optronics PictureFrame
Definiens Tissue Studio

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