Tubal sterilization and the risk of endometrial cancer

International Journal of Cancer. Journal International Du Cancer
X CastellsaguéR Dubrow

Abstract

Several animal and human studies suggest that tubal occlusion may curtail ovarian function, altering the production and balance of endogenous estrogens and progesterone, 2 hormones closely related to endometrial carcinogenesis. Despite this, and the increasing world-wide popularity of this method of contraception, little is known about its relationship with the risk of developing endometrial cancer. To assess whether tubal sterilization influences a woman's risk of developing epithelial endometrial carcinoma, data from a large multicenter population-based case-control study of endometrial cancer were analyzed. Cases were 437 women aged 20 to 54 years with histologically confirmed epithelial endometrial cancer ascertained through 6 population-based cancer registries in the United States. Controls were 3200 women selected at random from the populations of the areas from which the cases were detected. As compared with women who had never had tubal sterilization, women who had had this surgery had a crude odds ratio of 0.58 [95% confidence interval (CI), 0.43-0.78]. However, after adjusting for the combined confounding effects of age and parity, the magnitude of the protective association decreased to 0.87 (95% CI, 0.63-1.20). The ...Continue Reading

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Citations

Jul 7, 2000·Journal of Women's Health & Gender-based Medicine·N Visvanathan, G Wyshak
Jan 17, 2012·Hematology/oncology Clinics of North America·Daniel W Cramer
Nov 25, 2000·Obstetrics and Gynecology Clinics of North America·S Pati, V Cullins
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Oct 13, 2019·BMC Cancer·Laleh LoghmaniAmir Almasi-Hashiani
Mar 28, 1997·International Journal of Cancer. Journal International Du Cancer·K Rosenblatt, D Thomas

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