Tube Voltage, DNA Double-Strand Breaks, and Image Quality in Coronary CT Angiography

Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Zhu Xiao LinLong Jiang Zhang

Abstract

To evaluate the effects of tube voltage on image quality in coronary CT angiography (CCTA), the estimated radiation dose, and DNA double-strand breaks (DSBs) in peripheral blood lymphocytes to optimize the use of CCTA in the era of low radiation doses. This study included 240 patients who were divided into 2 groups according to the DNA DSB analysis methods, i.e., immunofluorescence microscopy and flow cytometry. Each group was subdivided into 4 subgroups: those receiving CCTA only with different tube voltages of 120, 100, 80, or 70 kVp. Objective and subjective image quality was evaluated by analysis of variance. Radiation dosages were also recorded and compared. There was no significant difference in demographic characteristics between the 2 groups and 4 subgroups in each group (all p > 0.05). As tube voltage decreased, both image quality and radiation dose decreased gradually and significantly. After CCTA, γ-H2AX foci and mean fluorescence intensity in the 120-, 100-, 80-, and 70-kVp groups increased by 0.14, 0.09, 0.07, and 0.06 foci per cell and 21.26, 9.13, 8.10, and 7.13 (all p < 0.05), respectively. The increase in the DNA DSB level in the 120-kVp group was higher than those in the other 3 groups (all p < 0.05), while th...Continue Reading

References

Apr 9, 2004·Lancet·Amy Berrington de González, Sarah Darby
Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Markus LöbrichMichael Uder
Jul 5, 2008·Nature Protocols·Aida MuslimovicOla Hammarsten
Feb 2, 2010·Mutation Research·Isabelle CorreFrancois Paris
Apr 7, 2010·Free Radical Biology & Medicine·Jean CadetJean-Luc Ravanat
May 21, 2011·European Journal of Radiology·Laurence BeelsHubert Thierens
Jul 5, 2011·Journal of Cardiovascular Computed Tomography·Sandra S HalliburtonUNKNOWN Society of Cardiovascular Computed Tomography
Apr 14, 2012·JACC. Cardiovascular Imaging·Gerald S BloomfieldPamela S Douglas
Jun 25, 2013·European Heart Journal·Michael FiechterPhilipp A Kaufmann
Nov 5, 2013·The International Journal of Cardiovascular Imaging·Sang Min LeeJae Hyung Park
Jul 27, 2015·JACC. Cardiovascular Imaging·Patricia K NguyenJoseph C Wu
Apr 10, 2016·Cytometry. Part B, Clinical Cytometry·Pegah JohanssonOla Hammarsten
Feb 22, 2017·Journal of Thoracic Imaging·Azadeh TabariMannudeep Kalra
Jul 24, 2018·Journal of Thoracic Imaging·Damiano CarusoAndrea Laghi

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
coronary artery bypass
density-gradient centrifugation
Fluorescence

Software Mentioned

FlowJo
Statistical Product and Service Solutions ( SPSS )
SAFIRE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.