PMID: 1181514Sep 1, 1975Paper

[Tuberculin allergy in BCG-vaccinated children (author's transl)].

Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft für Kinderheilkunde
T Luthardt, W Matthiä

Abstract

Frequency, duration and intensity of tuberculin allergy was tested in 431 children, vaccinated as neonates, and compared with the data of 400 non-vaccinated children, and 30 children with tuberculosis. When tested with 100 TE, 59% of the vaccinees showed a positive reaction at the age of 5 years, still 36% reacted positively in the 7th year. 4,7% of the non-vaccinated children were tuberculin-positive in 7--9 years old. Near half of the children reacting positively to tuberculin without suffering from tuberculosis reacted to 100 TE, nearly all tuberculous children already reacted positively to a lower dose. The overall rate of protection against tuberculosis was more than 90% in the first 5 years of life. Miliar-Tb. or Tb-meningitis was not seen in vaccinees, but 4 times in non protected children. General BCG-vaccination in newborns is recommended.

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.