PMID: 7538622May 27, 1995Paper

Tuberculosis and cancer: parallels in host responses and therapeutic approaches?

Lancet
John M GrangeG A Rook

Abstract

Mycobacteria elicit two quite different immune responses. One is protective and is partly based on recognition and lysis of stressed, bacilli-laden cells expressing heat-shock proteins. The other suppresses this recognition and instead leads to indiscriminate necrosis of tissues containing mycobacteria (the Koch phenomenon). The type of response depends on the predominant T-cell maturation pathway, Th1 or Th2, which in turn is determined by priming by prior contact with environmental mycobacteria. Vaccination by BCG induces whichever response the recipient is primed to make, and this is a likely explanation of the variable efficacy of this vaccine in prevention of tuberculosis and therapy of cancer. Thus; BCG is a two-edged sword. We postulate that by using other mycobacterial preparations, such as killed Mycobacterium vaccae, it might be possible to suppress the indiscriminate necrosis and enhance Th1-regulated selective destruction of tumour cells.

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Citations

Sep 21, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J StebbingS Mudan
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K J O'ByrneA L Harris
Jul 21, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mary E R O'Brien
May 23, 2015·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Young Bum ChoGeom Seog Seo
Mar 1, 2012·International Journal of Mycobacteriology·John Stanford, Cynthia Stanford
Sep 17, 2002·The Journal of Investigative Dermatology·Annette PfahlbergOlaf Gefeller
Sep 28, 2002·International Journal of Cancer. Journal International Du Cancer·Annette PfahlbergOlaf Gefeller
Oct 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deirdre O'MahonyMartin E Gutierrez
Dec 13, 2006·Memórias do Instituto Oswaldo Cruz·Rodrigo Gay DucatiDiógenes Santiago Santos
Jul 27, 2001·Tropical Medicine & International Health : TM & IH·Y StienstraT S van der Werf
Sep 17, 2003·Toxicology and Industrial Health·Giuseppe MastrangeloJohn H Lange
Jul 10, 1998·FEMS Immunology and Medical Microbiology·M L BayJ Stanford
May 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J StebbingS Mudan

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