Tuberculosis and the art of macrophage manipulation.

Pathogens and Disease
S UpadhyayJ A Philips

Abstract

Macrophages are first-line responders against microbes. The success of Mycobacterium tuberculosis (Mtb) rests upon its ability to convert these antimicrobial cells into a permissive cellular niche. This is a remarkable accomplishment, as the antimicrobial arsenal of macrophages is extensive. Normally bacteria are delivered to an acidic, degradative lysosome through one of several trafficking pathways, including LC3-associated phagocytosis (LAP) and autophagy. Once phagocytozed, the bacilli are subjected to reactive oxygen and nitrogen species, and they induce the expression of proinflammatory cytokines, which serve to augment host responses. However, Mtb hijacks these host defense mechanisms, manipulating host cellular trafficking, innate immune responses, and cell death pathways to its benefit. The complex series of measures and countermeasures between host and pathogen ultimately determines the outcome of infection. In this review, we focus on the diverse effectors that Mtb uses in its multipronged effort to subvert the innate immune responses of macrophages. We highlight recent advances in understanding the molecular interface of the Mtb-macrophage interaction.

References

Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J KeaneH Kornfeld
Jul 4, 2001·Nature Cell Biology·F KanaiM B Yaffe
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·K M EdwardsD S Kernodle
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura M SlyW Robert McMaster
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Rutilio A FrattiVojo Deretic
Jul 23, 2003·Nature Medicine·Ulrich E SchaibleStefan H E Kaufmann
Oct 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tsungda HsuWilliam R Jacobs
Oct 25, 2003·Science·John D MacMickingJohn D McKinney
May 4, 2004·Molecular and Cellular Biology·Otilia V VieiraSergio Grinstein
Jun 24, 2004·The Journal of Biological Chemistry·Jennifer Chua, Vojo Deretic
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jessica L FlintKeith M Derbyshire
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Isabelle VergneVojo Deretic
Oct 6, 2005·The Journal of Experimental Medicine·Peter B KangLarry S Schlesinger
Jan 18, 2006·Immunity·Florian WinauUlrich E Schaible
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Minjian ChenHeinz G Remold
Aug 5, 2006·Science·Sudha B SinghVojo Deretic
Sep 16, 2006·Science·Patricia A Digiuseppe ChampionJeffery S Cox
Sep 20, 2006·The Journal of Cell Biology·Esteban A RobertsVojo Deretic
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah A StanleyJeffery S Cox
Jul 31, 2007·PLoS Pathogens·Kamalakannan VelmuruganVolker Briken
Aug 3, 2007·The Journal of Clinical Investigation·Joseph HincheySteven A Porcelli
Apr 15, 2008·Cell Host & Microbe·Sharon S MasterVojo Deretic
Aug 30, 2008·FEMS Microbiology Letters·Christoph GrundnerTom Alber
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amy-Jo CasbonMary C Dinauer
Apr 17, 2009·Nature Reviews. Microbiology·Ronald S FlannaganSergio Grinstein
May 15, 2009·Cellular Microbiology·Sabine Ehrt, Dirk Schnappinger

❮ Previous
Next ❯

Citations

Jun 6, 2019·Annual Review of Biomedical Engineering·Nikhil JainViola Vogel
Jun 21, 2019·Microorganisms·Rachael A FiewegerBrian C VanderVen
Mar 6, 2019·Journal of Bacteriology·Rachel E BossermanPatricia A Champion
Jan 31, 2020·Frontiers in Molecular Biosciences·Katherine FennVidya Chandran Darbari
Sep 4, 2020·Microbiology and Molecular Biology Reviews : MMBR·Alexandra E ChirakosPatricia A Champion
Mar 20, 2020·Seminars in Immunopathology·Benedict Brazier, Helen McShane
Feb 7, 2019·Pathogens and Disease·McDonough Kathleen, Brennan Patrick
Nov 16, 2019·Signal Transduction and Targeted Therapy·Yang LiWeibing Yang
Sep 10, 2020·Infection and Immunity·Alexandra E ChirakosPatricia A Champion
Jan 25, 2021·Experimental Eye Research·Ruchi ShahAlexander V Ljubimov
Oct 16, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Cao RuanJianping Xie
Nov 18, 2019·The American Journal of Pathology·Thao K T NguyenJeffrey K Actor
Dec 18, 2020·Frontiers in Cellular and Infection Microbiology·Kuldeep Sachdeva, Varadharajan Sundaramurthy
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Jacques Augenstreich, Volker Briken
Mar 6, 2021·PloS One·Luciane Costa DalboniMaria Anete Lallo
Nov 13, 2020·Signal Transduction and Targeted Therapy·Yang LiWeibing Yang
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Xiaohui YuanHongyu Sun
Apr 16, 2021·PLoS Pathogens·Giorgia MoriAntje Blumenthal
Aug 11, 2019·Microbiology Spectrum·Vincent J C van WindenMiriam Braunstein
Oct 26, 2021·Frontiers in Immunology·Cilian Ó MaoldomhnaighJoseph Keane

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Related Papers

Cytokine & Growth Factor Reviews
Samantha R Slight, Shabaana A Khader
Cell Death and Differentiation
A Orvedahl, Beth Levine
Microbiology and Immunology
Shivendra K Chaurasiya
© 2022 Meta ULC. All rights reserved