PMID: 9434331Jun 1, 1996Paper

Tuberculosis antigen A60 serodiagnosis in tuberculous infection: application in extrapulmonary and smear-negative pulmonary tuberculosis

Respirology : Official Journal of the Asian Pacific Society of Respirology
K T LuhL N Lee

Abstract

An ELISA diagnostic test for tuberculosis antigen A60 (TBA60) IgG/IgM was used in a tertiary referral hospital in Taiwan. From June 1992 to December 1993, serum samples obtained from 907 patients were analyzed for TBA60 IgG and IgM titres. The final diagnosis of these patients was confirmed by microbiological study and clinical follow up for 18-24 months. Among 147 patients with active pulmonary tuberculosis, IgG was positive in 112 (76.2%), IgM was positive in 14 (9.52%). Among 90 patients with active extrapulmonary tuberculosis, IgG was positive in 53 (58.9%), IgM was positive in 9 (10%). Among 153 patients with inactive tuberculosis, IgG was positive in 28 (18.3%), IgM was positive in 1 (1.6%). Among 517 patients with nontuberculous disease, IgG was positive in 50 (9.7%), IgM was positive in 3 (0.6%). In this study population with 26% (237/907) active tuberculous infection rate, the TBA60 ELISA IgG had a diagnostic sensitivity of 69.6% and a specificity of 92.1%. These results indicate a positive predictive value of 67.9% and a negative predictive value of 89.2%. The sensitivity of IgM was 10.5% and specificity, 99.4%. The serum IgG tire had good correlation with the extent of pulmonary TB had a higher percentage of IgG sero...Continue Reading

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Citations

Jul 1, 2003·Indian Journal of Clinical Biochemistry : IJCB·Swati BanerjeeBhaskar C Harinath
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·I H ChiangP C Yang
Jan 18, 2003·Paediatric Respiratory Reviews·G de Charnace, C Delacourt
Oct 19, 2007·FEMS Immunology and Medical Microbiology·Raj Kumar Verma, Amita Jain
Apr 2, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E KunterS Cavuslu
Jul 20, 2007·Scandinavian Journal of Immunology·F AbebeG Bjune

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