Tuberculosis Caused by Mycobacterium africanum, United States, 2004-2013

Emerging Infectious Diseases
Aditya SharmaEleanor S Click

Abstract

Mycobacterium africanum is endemic to West Africa and causes tuberculosis (TB). We reviewed reported cases of TB in the United States during 2004-2013 that had lineage assigned by genotype (spoligotype and mycobacterial interspersed repetitive unit variable number tandem repeats). M. africanum caused 315 (0.4%) of 73,290 TB cases with lineage assigned by genotype. TB caused by M. africanum was associated more with persons from West Africa (adjusted odds ratio [aOR] 253.8, 95% CI 59.9-1,076.1) and US-born black persons (aOR 5.7, 95% CI 1.2-25.9) than with US-born white persons. TB caused by M. africanum did not show differences in clinical characteristics when compared with TB caused by M. tuberculosis. Clustered cases defined as >2 cases in a county with identical 24-locus mycobacterial interspersed repetitive unit genotypes, were less likely for M. africanum (aOR 0.1, 95% CI 0.1-0.4), which suggests that M. africanum is not commonly transmitted in the United States.

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Citations

Apr 6, 2019·Open Forum Infectious Diseases·Arpita ChakravartiChristian Lavallée
Sep 26, 2019·Frontiers in Microbiology·Baltazar CáMargarida Saraiva
Sep 14, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marcelo Fouad RabahiPhilip Noel Suffys
Jan 14, 2017·Microbiology Spectrum·Jaime Esteban, Maria-Carmen Muñoz-Egea
May 18, 2021·New Microbes and New Infections·M FellagM Drancourt
Jun 14, 2021·BMC Infectious Diseases·Vegard EldholmTrude Arnesen
Oct 5, 2021·Lipids in Health and Disease·Daniel MekonnenAbraham Aseffa

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Methods Mentioned

BETA
genotyping

Software Mentioned

R

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