Tuberculosis control in South African gold mines: mathematical modeling of a trial of community-wide isoniazid preventive therapy

American Journal of Epidemiology
Emilia VynnyckyRichard G White

Abstract

A recent major cluster randomized trial of screening, active disease treatment, and mass isoniazid preventive therapy for 9 months during 2006-2011 among South African gold miners showed reduced individual-level tuberculosis incidence but no detectable population-level impact. We fitted a dynamic mathematical model to trial data and explored 1) factors contributing to the lack of population-level impact, 2) the best-achievable impact if all implementation characteristics were increased to the highest level achieved during the trial ("optimized intervention"), and 3) how tuberculosis might be better controlled with additional interventions (improving diagnostics, reducing treatment delay, providing isoniazid preventive therapy continuously to human immunodeficiency virus-positive people, or scaling up antiretroviral treatment coverage) individually and in combination. We found the following: 1) The model suggests that a small proportion of latent infections among human immunodeficiency virus-positive people were cured, which could have been a key factor explaining the lack of detectable population-level impact. 2) The optimized implementation increased impact by only 10%. 3) Implementing additional interventions individually and...Continue Reading

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References

Oct 1, 1993·American Journal of Industrial Medicine·E HnizdoR G Thomas
Jun 1, 1996·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·R L Cowie
Oct 1, 1996·American Journal of Respiratory and Critical Care Medicine·R E ChaissonN A Halsey
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·E L CorbettR J Hayes
Oct 31, 2001·AIDS·J L JohnsonUNKNOWN Uganda-Case Western Reserve University Research Collaboration
Jun 12, 2004·American Journal of Respiratory and Critical Care Medicine·Elizabeth L CorbettGavin J Churchyard
Feb 9, 2005·Current Opinion in Pulmonary Medicine·Binaya RimalWilliam N Rom
Oct 21, 2006·The Journal of Infectious Diseases·Brian G WilliamsChristopher Dye
Jul 25, 2008·Sexually Transmitted Infections·L AlkemaT Brown
Sep 12, 2009·American Journal of Respiratory and Critical Care Medicine·James J LewisGavin J Churchyard
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Brian G WilliamsChristopher Dye
Dec 14, 2011·The New England Journal of Medicine·Timothy R SterlingUNKNOWN TB Trials Consortium PREVENT TB Study Team
Dec 27, 2011·Drug Discovery Today·Hanif EsmailRobert J Wilkinson
May 16, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·C L van HalsemaA D Grant
Oct 31, 2012·Bulletin of the World Health Organization·Hsien-Ho LinTed Cohen
Jan 24, 2014·The New England Journal of Medicine·Gavin J ChurchyardUNKNOWN Thibela TB Study Team

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Citations

Feb 13, 2016·American Journal of Epidemiology·Alice ZwerlingDavid W Dowdy
Feb 13, 2016·The Lancet Infectious Diseases·Tom A YatesIbrahim Abubakar
Jun 1, 2016·Frontiers in Microbiology·Robert S Wallis
Apr 26, 2017·Journal of the International AIDS Society·Colleen F Hanrahan, Annelies Van Rie
Nov 8, 2017·The Journal of Infectious Diseases·David W DowdyDavid A J Moore
Nov 8, 2017·The Journal of Infectious Diseases·Richard D TurnerKevin P Fennelly
Dec 31, 2017·BMC Medicine·M Elizabeth HalloranMarc Lipsitch
Nov 2, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James M TrauerDavid W Dowdy
Jun 14, 2018·Nature Reviews. Immunology·Jason D SimmonsThomas R Hawn

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