Tuberculosis Diagnosis in Children Using Xpert Ultra on Different Respiratory Specimens.

American Journal of Respiratory and Critical Care Medicine
Heather J ZarMark P Nicol

Abstract

Rationale: Microbiological confirmation of pulmonary tuberculosis in children is desirable.Objectives: To investigate the diagnostic accuracy and incremental yield of Xpert MTB/RIF Ultra (Ultra; Cepheid), a new rapid test, on repeated induced sputum, nasopharyngeal aspirates, and combinations of specimens.Methods: Consecutive South African children hospitalized with suspected pulmonary tuberculosis were enrolled.Measurements and Main Results: Induced sputum (IS) and nasopharyngeal aspirates (NPAs) were obtained. NPAs were frozen; IS underwent liquid culture, and an aliquot was frozen. Ultra was performed on thawed NPAs and IS specimens individually. Children were categorized as confirmed, unconfirmed, or unlikely tuberculosis according to NIH consensus case definitions. The diagnostic accuracy of Ultra was compared with liquid culture on IS. In total, 195 children (median age: 23.3 mo; 32 [16.4%] HIV-infected) had one IS and NPA, and 130 had two NPAs. There were 40 (20.5%) culture-confirmed cases. Ultra was positive on NPAs in 26 (13.3%) and on IS in 31 (15.9%). Sensitivity and specificity of Ultra on one NPA were 46% and 98%, respectively, and similar by HIV status. Sensitivity and specificity of Ultra on one IS were 74.3% and...Continue Reading

References

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Nov 13, 2018·The Pediatric Infectious Disease Journal·Elisabetta WaltersAnneke C Hesseling

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Citations

May 30, 2020·American Journal of Respiratory and Critical Care Medicine
Aug 28, 2020·The Cochrane Database of Systematic Reviews·Alexander W KayAnna M Mandalakas
Sep 24, 2020·Expert Review of Respiratory Medicine·James A SeddonH Simon Schaaf
Aug 8, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben J Marais
Oct 1, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Rafaela Baroni AurilioClemax Couto Sant'Anna
Mar 17, 2020·American Journal of Respiratory and Critical Care Medicine·Saurav JainJagdish Prasad Goyal
Mar 17, 2020·American Journal of Respiratory and Critical Care Medicine·Heather J Zar
May 26, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James Gaensbauer
Aug 7, 2019·American Journal of Respiratory and Critical Care Medicine·H Simon Schaaf, Ben J Marais
Jan 9, 2021·Journal of the Pediatric Infectious Diseases Society·Devan JaganathAdithya Cattamanchi
Feb 23, 2021·JAMA Pediatrics·Jeffrey R Starke, Andrea T Cruz
Sep 29, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Chunyang LyuYongmei Jiang
Nov 5, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Xiaoshan PengChaomin Wan
Nov 15, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Lin SunAdong Shen

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Methods Mentioned

BETA
PCR

Software Mentioned

GeneXpert
Ultra

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