Tuberculosis diagnostics in 2015: landscape, priorities, needs, and prospects

The Journal of Infectious Diseases
Madhukar Pai, Marco Schito

Abstract

In 2015, tuberculosis remains a major global health problem, and drug-resistant tuberculosis is a growing threat. Although tuberculosis diagnosis in many countries is still reliant on older tools, new diagnostics are changing the landscape. Stimulated, in part, by the success and roll out of Xpert MTB/RIF, there is now considerable interest in new technologies. The landscape looks promising, with a robust pipeline of new tools, particularly molecular diagnostics, and well over 50 companies actively engaged in product development. However, new diagnostics are yet to reach scale, and there needs to be greater convergence between diagnostics development and development of shorter-duration tuberculosis drug regimens. Another concern is the relative absence of non-sputum-based diagnostics in the pipeline for children and of biomarker tests for triage, cure, and progression of latent Mycobacterium tuberculosis infection. Several initiatives, described in this supplement, have been launched to further stimulate product development and policy, including assessment of needs and priorities, development of target product profiles, compilation of data on resistance-associated mutations, and assessment of market size and potential for new d...Continue Reading

References

Jan 24, 2007·Antimicrobial Agents and Chemotherapy·Elvira RichterDoris Hillemann
Nov 29, 2011·Tuberculosis·James A SeddonH Simon Schaaf
Dec 22, 2012·Expert Review of Molecular Diagnostics·Dimitrios H Roukos
Dec 22, 2012·The European Respiratory Journal·Andrea PantojaKatherine Floyd
Mar 28, 2013·The Lancet Infectious Diseases·William A WellsMarco Schito
Apr 2, 2013·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·C M DenkingerM Pai
Apr 12, 2013·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·Madhukar Pai
May 1, 2013·Nature Reviews. Drug Discovery·Alimuddin ZumlaStewart T Cole
May 4, 2013·Expert Review of Molecular Diagnostics·Madhukar Pai
Aug 2, 2013·The European Respiratory Journal·Claudia M DenkingerMadhukar Pai
Oct 15, 2013·The Lancet Infectious Diseases·Wim Van Biesen, Achim Jörres
Oct 25, 2013·Expert Review of Molecular Diagnostics·Claudia M DenkingerMadhukar Pai
Jan 5, 2014·BMC Infectious Diseases·Jacob CreswellLucica Ditiu
Feb 15, 2014·The European Respiratory Journal·Sandra V KikMadhukar Pai
Apr 4, 2014·The European Respiratory Journal·Sandra V KikMadhukar Pai
May 3, 2014·The New England Journal of Medicine·Suzanne T AndersonBrian Eley
Aug 8, 2014·PloS One·UNKNOWN TB Diagnostics Market Analysis Consortium
Aug 12, 2014·The Lancet Global Health·Peter J DoddJames A Seddon
Aug 22, 2014·The Pediatric Infectious Disease Journal·Nkosilesisa MpofuMark Hatherill
Jan 13, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·UNKNOWN TB Diagnostics Market Analysis Consortium
Mar 15, 2015·The Journal of Infectious Diseases·Claudia M DenkingerMadhukar Pai
Mar 15, 2015·The Journal of Infectious Diseases·Claudia M DenkingerMark D Perkins
Mar 15, 2015·The Journal of Infectious Diseases·Hugh SalamonDavid L Dolinger
Mar 15, 2015·The Journal of Infectious Diseases·Sandra V KikMadhukar Pai
Mar 15, 2015·The Journal of Infectious Diseases·Andrea PantojaClaudia M Denkinger

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Citations

Jan 23, 2016·Diagnostic Cytopathology·Pamela MichelowColleen Wright
Oct 20, 2015·Expert Opinion on Pharmacotherapy·Emanuele PontaliGiovanni Battista Migliori
Jul 19, 2015·The Lancet Global Health·Frauke Rudolf, Christian Wejse
Feb 20, 2016·Expert Review of Molecular Diagnostics·David R Murdoch
Sep 27, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark Patrick NicolGerhard Walzl
Sep 27, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ivor LangleyAfrânio Kritski
Jun 9, 2016·Expert Review of Respiratory Medicine·Alberto MatteelliGiovanni Battista Migliori
Oct 31, 2015·Lancet·Katrina F OrtbladRifat Atun
Sep 24, 2016·Cell Chemical Biology·Ting-Yen Wei, Chao-Min Cheng
Sep 25, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E AndreE Cambau
Nov 29, 2016·Expert Review of Molecular Diagnostics·Emily MacLeanMadhukar Pai
Feb 6, 2017·American Journal of Infection Control·Sanchita DasMichael O Vernon
Jan 28, 2017·Journal of Medical Microbiology·Kamal ShrivastavaMandira Varma-Basil
Jun 29, 2017·EBioMedicine·Charles M BarkEustache Paramithiotis
Mar 10, 2018·Future Microbiology·Anthony L ByrneBen J Marais
Jul 6, 2018·PloS One·Nitu ThakoreRebecca C Holmberg
Aug 2, 2015·The European Respiratory Journal·Ruvandhi R Nathavitharana, Jon S Friedland
Nov 22, 2018·Journal of Clinical Laboratory Analysis·Jie LuZuosen Yang
Oct 28, 2016·Nature Reviews. Disease Primers·Madhukar PaiMario Raviglione
Dec 20, 2015·EMBO Molecular Medicine·Jeroen MaertzdorfStefan He Kaufmann
Oct 28, 2019·Science Translational Medicine·Rushdy AhmadMichael A Gillette
Feb 25, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·James G CarlucciUNKNOWN International Epidemiology Databases to Evaluate AIDS (IeDEA) Network
Jan 5, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jian DuYu Pang

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