Tuberculosis in Anti-Tumour Necrosis Factor-treated Inflammatory Bowel Disease Patients After the Implementation of Preventive Measures: Compliance With Recommendations and Safety of Retreatment

Journal of Crohn's & Colitis
D CarpioGETECCU

Abstract

Despite having adopted preventive measures, tuberculosis (TB) may still occur in patients with inflammatory bowel disease (IBD) treated with anti-tumour necrosis factor (anti-TNF). Data on the causes and characteristics of TB cases in this scenario are lacking. Our aim was to describe the characteristics of TB in anti-TNF-treated IBD patients after the publication of the Spanish TB prevention guidelines in IBD patients and to evaluate the safety of restarting anti-TNF after a TB diagnosis. In this multicentre, retrospective, descriptive study, TB cases from Spanish hospitals were collected. Continuous variables were reported as mean and standard deviation or median and interquartile range. Categorical variables were described as absolute and relative frequencies and their confidence intervals when necessary. We collected 50 TB cases in anti-TNF-treated IBD patients, 60% male, median age 37.3 years (interquartile range [IQR] 30.4-47). Median latency between anti-TNF initiation and first TB symptoms was 155.5 days (IQR 88-301); 34% of TB cases were disseminated and 26% extrapulmonary. In 30 patients (60%), TB cases developed despite compliance with recommended preventive measures; *not performing 2-step TST (tuberculin skin test)...Continue Reading

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Citations

Feb 6, 2018·Journal of Crohn's & Colitis·Henning TrawinskiChristoph Lübbert
Sep 1, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Esther Merino GallegoFrancisco Javier Gallego Rojo
Jul 28, 2018·Journal of Crohn's & Colitis·Carlos TaxoneraUNKNOWN CONVERT study group from GETECCU
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Mar 24, 2017·Journal of Crohn's & Colitis·Carlos TaxoneraUNKNOWN SEGURTB study group from GETECCU
Jun 20, 2019·The New England Journal of Medicine·Hamed KhaliliLawrence R Zukerberg
Jan 26, 2021·International Journal of Inflammation·Adam KrusińskiJanusz Milanowski

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