PMID: 9438645Jan 23, 1998Paper

Tuberculosis in childhood nephrotic syndrome in India

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
S GulatiR Gujral

Abstract

We studied the prevalence, clinical features, and impact of tuberculosis (TB) on children with nephrotic syndrome (NS). Of the 300 children with NS, 28 (9.3%) were diagnosed as having TB. This occurred following the initiation of immunosuppressive therapy in 27 children, and in 1 child it preceded the onset of NS. Pulmonary involvement was the commonest (22/28), followed by tubercular lymphadenitis (2/28), meningitis (2/28), and occult TB (2/28). Of the various diagnostic criteria, history of previous cough, fever, or exposure to a case of TB (23/28) and chest skiagram (21/28) were the most useful. The occurrence of TB did not induce a relapse or affect the subsequent response to steroid therapy (as is often seen with other infections) or have a deleterious effect on renal function. Patients who received higher doses of steroids (frequent relapsers, steroid dependent, initial non-responders, and subsequent non-responders) had a significantly higher prevalence of TB (19/148) than those who received lower doses (infrequent relapsers 8/151) (P = 0.04). We thus found TB to be an important complication of children with NS in our country. The conventional diagnostic tests, such as Mantoux and acid-fast bacilli isolation, are often un...Continue Reading

Citations

Apr 15, 1999·Current Opinion in Pediatrics·R W Chesney
Jan 21, 2016·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·H BarmanS G Duwarah
Sep 16, 2008·Critical Reviews in Oncology/hematology·Justine BacchettaJean-Pierre Droz
Nov 17, 2011·Korean journal of pediatrics·Se Jin Park, Jae Il Shin
May 9, 2015·The International Journal of Artificial Organs·Shu LiZheng Wang
Nov 20, 2019·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Kanika RanaRavi Meher

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