Tuberculosis in Liver Transplant Recipients: A Report of Eight Cases During a Five Year Period

Acta Médica Portuguesa
Diana PóvoasEduardo Barroso

Abstract

Tuberculosis incidence in Portugal ranged from 20 to 22 cases per 100 000 inhabitants between 2010 and 2014. Tuberculosis incidence in liver transplant recipients is not precisely known, but it is estimated to be higher than among the general population. Tuberculosis in liver transplant recipients is particularly challenging because of the atypical clinical presentation and side effects of the antibacillary drugs and their potential interactions with immunosuppressive therapies. We retrospectively reviewed the clinical records of liver transplant recipients with post-transplant tuberculosis occurring from January 2010 to December 2014 at a liver transplantation unit in Lisbon, Portugal. Demographic data, baseline and clinical features, as well as treatment regimen, toxicities and outcomes, were analyzed. Among 1005 recipients, active tuberculosis was diagnosed in eight patients between January 2010 and December 2014 (frequency = 0.8%). Late onset tuberculosis was more frequent than early tuberculosis. Mycobacterium tuberculosis complex was isolated from cultures in almost every case (7; 87.5%). Extra-pulmonary involvement and disseminated tuberculosis were frequent. Two patients developed rejection without allograft loss. Crude...Continue Reading

Citations

May 26, 2017·Current Opinion in Organ Transplantation·Stephanie A K AngaritaFady M Kaldas
Jul 26, 2019·World Journal of Gastroenterology : WJG·Jose Tiago SilvaJosé María Aguado
May 8, 2021·Case Reports in Transplantation·Wanessa T ClementeMarcelo Dias Sanches
Mar 23, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christianne BourlonAlfredo Ponce-de-León

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