Tuberculosis: opportunities and challenges for the 90-90-90 targets in HIV-infected children

Journal of the International AIDS Society
Helena RabieAnthony J Garcia-Prats

Abstract

In 2014 the Joint United Nations Programme on HIV/AIDS defined the ambitious 90-90-90 targets for 2020, in which 90% of people living with HIV must be diagnosed, 90% of those diagnosed should be on sustained therapy and 90% of those on therapy should have an undetectable viral load. Children are considered to be a key focus population for these targets. This review will highlight key components of the epidemiology, prevention and treatment of tuberculosis (TB) in HIV-infected children in the era of increasing access to antiretroviral therapy (ART) and their relation to the 90-90-90 targets. The majority of HIV-infected children live in countries with a high burden of TB. In settings with a high burden of both diseases such as in sub-Saharan Africa, up to 57% of children diagnosed with and treated for TB are HIV-infected. TB results in substantial morbidity and mortality in HIV-infected children, so preventing TB and optimizing its treatment in HIV-infected children will be important to ensuring good long-term outcomes. Prevention of TB can be achieved by increasing access to ART to both children and adults, and appropriate provision of isoniazid preventative therapy. Co-treatment of HIV and TB is complicated by drug-drug intera...Continue Reading

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Citations

Dec 8, 2015·Journal of the International AIDS Society·Mary-Ann Davies, Jorge Pinto
Jan 1, 2015·Journal of the International AIDS Society·Mary-Ann DaviesMarlène Bras
Jul 14, 2017·Pneumonia·Helena Rabie, Pierre Goussard
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May 27, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer Furin, Helen Cox

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT01637558
NCT01687504
NCT01856634
NCT01859923
NCT02348177
NCT01751568

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