Tuberculosis origin: The Neolithic scenario

Tuberculosis
Israel HershkovitzGila Kahila Bar-Gal

Abstract

This paper follows the dramatic changes in scientific research during the last 20 years regarding the relationship between the Mycobacterium tuberculosis complex and its hosts - bovids and/or humans. Once the M. tuberculosis and Mycobacterium bovis genomes were sequenced, it became obvious that the old story of M. bovis evolving into the human pathogen should be reversed, as M. tuberculosis is more ancestral than M. bovis. Nevertheless, the timescale and geographical origin remained an enigma. In the current study human and cattle bone samples were examined for evidence of tuberculosis from the site of Atlit-Yam in the Eastern Mediterranean, dating from 9250 to 8160 (calibrated) years ago. Strict precautions were used to prevent contamination in the DNA analysis, and independent centers used to confirm authenticity of findings. DNA from five M. tuberculosis genetic loci was detected and had characteristics consistent with extant genetic lineages. High performance liquid chromatography was used as an independent method of verification and it directly detected mycolic acid lipid biomarkers, specific for the M. tuberculosis complex. These, together with pathological changes detected in some of the bones, confirm the presence of th...Continue Reading

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Citations

Feb 18, 2016·Pathogens and Global Health·Stefano GaiarsaDavide Sassera
Jun 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Tao LuoQian Gao
Aug 19, 2016·Proceedings. Biological Sciences·Mark Achtman
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Sep 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Do-Hee KimBong-Jin Lee
Nov 24, 2018·The Veterinary Record·Rob Kelly
Sep 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Fangfang ChenFrank Pessler
Mar 3, 2020·PLoS Neglected Tropical Diseases·Osvaldo Frederico InlameaTeresa Rito
Feb 16, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Junli LiChuan Qin
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Jun 11, 2021·BMC Cancer·Guang-Liang ChenDong-Mei Ji
Jul 12, 2021·Microbial Pathogenesis·Ali TaghipourFatemeh Ghaffarifar

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