Tuberculosis: treatment failure, or failure to treat? Lessons from India and South Africa

BMJ Global Health
Nesri PadayatchiMadhukar Pai

Abstract

Tuberculosis (TB) remains an enormous public health concern globally. India and South Africa rank among the top 10 high TB burden countries with the highest absolute burden of TB, and the second highest rate of TB incidence, respectively. Although the primary drivers of TB transmission vary considerably between these two countries, they do indeed share common themes. In 2017, only 64% of the global estimated incident cases of TB were reported, the remaining 36% of 'missing' cases were either undiagnosed, untreated or unreported. These 'missing TB cases' have generated much hype for the challenges they present in achieving the End TB Strategy. Although India and South Africa have indeed made significant strides in TB control, analysis of the patient cascade of care clearly suggests that these 'missed' patients are not really missing-most are actively engaging the health system-the system, however, is failing to appropriately manage them. In short, quality of TB care is suboptimal and must urgently be addressed, merely focusing on coverage of TB services is no longer sufficient. While the world awaits revolutionary vaccines, drugs and diagnostics, programmatic data indicate that much can be done to accelerate the decline of TB. I...Continue Reading

References

Oct 31, 2009·Bulletin of the World Health Organization·Michael PeckDehran Swart
May 17, 2011·Journal of Global Infectious Diseases·Indrajit Hazarika
May 17, 2011·PloS One·William A WellsMichael E Kimerling
Jul 12, 2011·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·S S Van WykA C Hesseling
Jan 25, 2012·Bulletin of the World Health Organization·Ben Jones, Amy Jing
Apr 12, 2013·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M M ClaassensN Beyers
Mar 29, 2014·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·C T SreeramareddyM Pai
Jun 5, 2014·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·G J ChurchyardY Pillay
Nov 2, 2014·The European Respiratory Journal·Zhi Zhen QinJacob Creswell
Apr 8, 2015·PloS One·Gwenan M KnightRichard G White
Jun 10, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·S SatyanarayanaM Pai
Aug 14, 2015·The Lancet Infectious Diseases·Jishnu DasMadhukar Pai
Feb 18, 2016·Transactions of the Royal Society of Tropical Medicine and Hygiene·Madhukar PaiSrinath Satyanarayana
Aug 24, 2016·BMC Complementary and Alternative Medicine·Thembelihle ZumaMosa Moshabela
Oct 30, 2016·The Lancet Infectious Diseases·Nimalan ArinaminpathyPuneet Dewan
Oct 31, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Danielle CazabonMadhukar Pai
Jun 8, 2017·BMJ Global Health·Madhukar PaiSoumitra S Bhuyan
Jul 22, 2017·The Lancet Global Health·Tedros Adhanom Ghebreyesus
Sep 2, 2017·The European Respiratory Journal·Danielle CazabonMadhukar Pai
Nov 9, 2017·The Journal of Infectious Diseases·Pren NaidooYogan Pillay
Nov 9, 2017·The Journal of Infectious Diseases·Daniel P Chin, Christy L Hanson
Feb 24, 2018·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·P F KwezaA Medina-Marino
Apr 13, 2018·International Journal of Environmental Research and Public Health·Carmen S ChristianRonelle Burger
Sep 10, 2018·The Lancet Global Health·Margaret E KrukMuhammad Pate

❮ Previous
Next ❯

Citations

Jan 8, 2020·Journal of Clinical Medicine·Michelle A BulterysTobias Broger
Jan 15, 2020·The American Journal of Tropical Medicine and Hygiene·Sakarn CharoensakulchaiPhunlerd Piyaraj
Jun 5, 2020·BMC Health Services Research·Ahmad FuadyJan Hendrik Richardus
Mar 18, 2020·Journal of Clinical Tuberculosis and Other Mycobacterial Diseases·Michael J A Reid, Eric Goosby
Jun 9, 2021·The Indian Journal of Tuberculosis·Gargi ThakurHarshad Thakur
Jun 11, 2021·BMC Cancer·Guang-Liang ChenDong-Mei Ji

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
Gavin ChurchyardYogan Pillay
Indian Journal of Endocrinology and Metabolism
Anthonia Okeoghene OgberaKofo Odeyemi
Bulletin de la Société de pathologie exotique
T Comolet
JAMA : the Journal of the American Medical Association
K M De CockK G Castro
© 2022 Meta ULC. All rights reserved