Stephen D Lawn, Alimuddin I Zumla


Tuberculosis results in an estimated 1·7 million deaths each year and the worldwide number of new cases (more than 9 million) is higher than at any other time in history. 22 low-income and middle-income countries account for more than 80% of the active cases in the world. Due to the devastating effect of HIV on susceptibility to tuberculosis, sub-Saharan Africa has been disproportionately affected and accounts for four of every five cases of HIV-associated tuberculosis. In many regions highly endemic for tuberculosis, diagnosis continues to rely on century-old sputum microscopy; there is no vaccine with adequate effectiveness and tuberculosis treatment regimens are protracted and have a risk of toxic effects. Increasing rates of drug-resistant tuberculosis in eastern Europe, Asia, and sub-Saharan Africa now threaten to undermine the gains made by worldwide tuberculosis control programmes. Moreover, our fundamental understanding of the pathogenesis of this disease is inadequate. However, increased investment has allowed basic science and translational and applied research to produce new data, leading to promising progress in the development of improved tuberculosis diagnostics, biomarkers of disease activity, drugs, and vaccines...Continue Reading

Associated Clinical Trials


May 26, 1999·International Journal of Epidemiology·E Vynnycky, P E Fine
Feb 3, 2005·Tuberculosis·Tom H M OttenhoffEsther van de Vosse
Aug 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul BrassardSamy Suissa
Jan 6, 2007·The Journal of Infectious Diseases·Rohit MistryPauline T Lukey
Feb 24, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marc JacobsenStefan H E Kaufmann
Jun 8, 2007·Emerging Infectious Diseases·N Sarita ShahJ Peter Cegielski
Aug 30, 2007·The Journal of Infectious Diseases·Charles D WellsKarin Weyer
Mar 3, 2009·BMC Infectious Diseases·Samantha RibeiroSusan E Dorman
Jun 18, 2009·Current Opinion in HIV and AIDS·Stephen D Lawn, Gavin Churchyard
Jul 25, 2009·American Journal of Respiratory and Critical Care Medicine·Patama MonkongdeeJay K Varma
Nov 21, 2009·Clinics in Chest Medicine·Madhukar PaiMark D Perkins
Nov 21, 2009·Clinics in Chest Medicine·Paul-Henri LambertWillem A Hanekom
Nov 21, 2009·The Lancet Infectious Diseases·Kelly E Dooley, Richard E Chaisson
Mar 26, 2010·The Lancet Infectious Diseases·Monika MüllerUNKNOWN IeDEA Southern and Central Africa
Apr 9, 2010·Current Opinion in Pulmonary Medicine·Jonathan PeterKeertan Dheda
Apr 30, 2010·Current Opinion in Pharmacology·Femke BaekeChantal Mathieu
May 22, 2010·Lancet·Stefan H E KaufmannPaul-Henri Lambert
May 22, 2010·Lancet·Anthony D HarriesKevin M De Cock
May 22, 2010·Lancet·Peter R DonaldClifton E Barry
May 22, 2010·Lancet·Knut LönnrothMario C Raviglione
Aug 28, 2010·The Lancet Infectious Diseases·José A CamineroGiovanni Battista Migliori
Feb 24, 2011·Tropical Medicine & International Health : TM & IH·Alimuddin ZumlaJohn Grange

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Nov 28, 2012·Lung·Cho NaingAni Izzuani Binti Mohd Kassim
Jul 5, 2013·Current HIV/AIDS Reports·Tejaswi KompalaGerald Friedland
Feb 22, 2013·The New England Journal of Medicine·Alimuddin ZumlaC Fordham von Reyn
Aug 19, 2011·The Journal of Infectious Diseases·C Fordham von Reyn
Oct 26, 2011·The Journal of Infectious Diseases·Victoria O KasprowiczAjit Lalvani
Apr 13, 2012·The Journal of Infectious Diseases·Ruth McNerneyAlimuddin Zumla
Oct 4, 2012·The Journal of Infectious Diseases·Devan Jaganath, Ezekiel Mupere
Feb 22, 2012·Current Opinion in Pulmonary Medicine·Alimuddin Zumla
Aug 25, 2012·TheScientificWorldJournal·Adrian Zaragoza BastidaNinfa Ramírez Durán
Oct 7, 2011·Clinical and Vaccine Immunology : CVI·Imran H KhanPaul A Luciw
Apr 5, 2013·Journal of Clinical Microbiology·Asa TapleyAdithya Cattamanchi
Dec 4, 2013·BMC Infectious Diseases·Mweete D NglaziCharles S Wiysonge
Aug 22, 2013·International Journal for Equity in Health·Bárbara Reis-SantosEthel L Maciel
Apr 6, 2013·BMC Medicine·Sreeram V RamagopalanMichael J Goldacre
Mar 19, 2013·PLoS Genetics·Lukas FennerUNKNOWN Swiss HIV Cohort and Molecular Epidemiology of Tuberculosis Study Groups
Apr 24, 2012·PloS One·Johannes NemethStefan Winkler

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