PMID: 11931732Apr 5, 2002Paper

Tuberculous Meningitis in Children

Current Treatment Options in Neurology
Norman J. Waecker

Abstract

Initial empiric treatment for central nervous system (CNS) tuberculosis should include four antituberculous drugs until results of cultures and sensitivities are available. Treatment should include isoniazid, rifampin, pyrazinamide, and either ethambutol or streptomycin. Total treatment should extend for 12 months. Daily therapy should be used for the first 2 months, followed by either twice a week treatment or continued with daily therapy for the duration with directly observed therapy (DOT). Pyrazinamide should be included in all treatment regimes for the first 2 months of therapy. Corticosteroids should be used in the management of children with tuberculous meningitis. Corticosteroids have been shown to decrease mortality, long-term neurologic complications, and permanent sequelae. Prednisone is often used at a dosage of 1 to 2 mg/kg per day. Steroids should be used for 4 to 6 weeks, and then tapered over the next 2 to 3 weeks. Cerebrospinal fluid (CSF) cultures and other infected sites must be aggressively pursued in order to obtain an organism for identification and sensitivities testing. Cranial CT scans with contrast should be included in the early diagnostic work-up of a child with suspected CNS tuberculosis infection. ...Continue Reading

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