Tuberous sclerosis complex

Anais Brasileiros De Dermatologia
Daniela Araujo RodriguesIzelda Maria Carvalho Costa

Abstract

Tuberous Sclerosis Complex, also known as Epiloia or Bourneville-Pringle disease is an autosomal dominant neurocutaneous syndrome with variable clinical expression. It is a multisystem disorder that may be associated with hamartomas in multiple organs in an unpredictable manner. The dermatologist plays an essential role in the history of the disease, since skin manifestations represent the most prevalent clinical features, enabling early diagnosis and intervention in its natural course. This article aims to inform the scientific community about advances made in the study of genetics and molecular biology. Recent findings regarding stimulation of tumor growth have been changing the history of this condition, making therapeutic trials with topical and systemic drugs possible. Knowledge of these topics enables better management of the patients affected, since tissue replacement by tumors can result in significant morbidity and mortality.

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Citations

Jan 13, 2017·Cell Death & Disease·Yuechen LuoXiaoming Feng
Oct 28, 2016·Head and Neck Pathology·Natália Galvão GarciaJoão Adolfo Costa Hanemann
Jun 18, 2017·Science China. Life Sciences·Dayong BaiXu Wang
Jun 21, 2018·Anais Brasileiros De Dermatologia·Larissa Karine Leite PortocarreroMaria Cecília da Matta Rivitti-Machado
Dec 24, 2014·International Journal of Dermatology·Januka GalahitiyawaMahel Galahitiyawa
Aug 31, 2019·Dermatologic Clinics·Benjamin Becker, Roy E Strowd
Jan 1, 2018·Anais Brasileiros De Dermatologia·Larissa Karine Leite PortocarreroMaria Cecília da Matta Rivitti-Machado
Mar 20, 2021·Acta neurologica Belgica·Mohammad BarzegarZakiyeh Ebadi
Mar 24, 2021·Seminars in Ophthalmology·Alessandro de PaulaGianluca Scuderi
May 18, 2021·Human Cell·Milad RafatKianoosh Malekzadeh

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