Tubo-Ovarian Transitional Cell Carcinoma and High-grade Serous Carcinoma Show Subtly Different Immunohistochemistry Profiles.

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Jamie MagrillFriedrich Kommoss

Abstract

Tubo-ovarian transitional cell carcinoma (TCC) is grouped with high-grade serous carcinoma (HGSC) in the current World Health Organization classification. TCC is associated with BRCA mutations and a better prognosis compared with HGSC. Previous papers examining the immunohistochemical features of TCC have studied limited numbers of samples. No marker reflecting the biological difference between TCC and HGSC is known. We collected a large cohort of TCC to determine whether TCC and HGSC could be distinguished by immunohistochemistry. A tissue microarray was built from 89 TCC and a control cohort of 232 conventional HGSC. Immunohistochemistry was performed, scored, and statistically analyzed for routine markers of HGSC and urothelial tumors: PAX8, WT1, p53, p16, ER, p63, and GATA3. Using scoring cutoffs commonly employed in clinical practice, the immunohistochemical profile of TCC was indistinguishable from HGSC for all markers. However, more detailed scoring criteria revealed statistically significant differences between the 2 groups of tumors with respect to ER, PAX8, and WT1. HGSC showed more diffuse and intense staining for PAX8 (P=0.004 and 0.001, respectively) and WT1 (P=0.002 and 0.002, respectively); conversely, TCC showed...Continue Reading

References

Apr 1, 1990·American Journal of Clinical Pathology·E G SilvaD M Gershenson
Jan 1, 1987·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R M Austin, H J Norris
Jul 1, 1996·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R A SoslowT A Longacre
Dec 1, 1996·Human Pathology·H C HollingsworthM J Merino
Jan 17, 2003·The New England Journal of Medicine·Lin ZhangGeorge Coukos
Sep 4, 2003·Journal of the National Cancer Institute·Andreas du BoisUNKNOWN Arbeitsgemeinschaft Gynäkologische Onkologie Ovarian Cancer Study Group
Apr 17, 2004·The American Journal of Surgical Pathology·John H Eichhorn, Robert H Young
Apr 17, 2004·The American Journal of Surgical Pathology·Anais MalpicaElvio G Silva
Mar 26, 2005·Gynecologic Oncology·Friedrich KommossUNKNOWN Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom
Aug 30, 2008·The American Journal of Surgical Pathology·Daisuke NonakaRobert A Soslow
Feb 19, 2010·International Journal of Surgical Pathology·Natalia BuzaVinita Parkash
Aug 5, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Helen J MackayUNKNOWN Gynecologic Cancer InterGroup
Dec 7, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Steve E KallogerC Blake Gilks
May 10, 2011·The American Journal of Surgical Pathology·Anna R LauryMichelle S Hirsch
May 10, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna YemelyanovaRobert J Kurman
Nov 2, 2011·Gynecologic Oncology·Wei-Ting HwangGeorge Coukos
Dec 24, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Robert A SoslowDouglas A Levine
Dec 30, 2011·The New England Journal of Medicine·Timothy J PerrenUNKNOWN ICON7 Investigators
Jan 26, 2012·JAMA : the Journal of the American Medical Association·Kelly L BoltonUNKNOWN Cancer Genome Atlas Research Network
Jan 28, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jessica N McAlpineC Blake Gilks
Jun 29, 2012·Oncology Letters·Satoshi IchigoAtsushi Imai
Sep 29, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Rola H AliC Blake Gilks
May 18, 2013·The American Journal of Surgical Pathology·Tadahisa TakeuchiYoshinao Oda
Mar 1, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M Carolina ReyesRobert A Soslow
Jan 13, 2015·The American Journal of Surgical Pathology·Brooke E HowittEmily E Meserve
Sep 16, 2016·British Journal of Cancer·Stefan KommossFriedrich Kommoss
Nov 15, 2016·The Journal of Pathology. Clinical Research·Martin KöbelJames D Brenton
Oct 25, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dale W GarsedUNKNOWN Nadia Traficante, for the Australian Ovarian Cancer Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.