Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases

The American Journal of Dermatopathology
Dmitry V KazakovMichal Michal

Abstract

The main controversies regarding tubular apocrine adenoma and papillary eccrine adenoma are whether they are two distinct entities or are the very same tumor, and if so, which lineage of differentiation (apocrine versus eccrine) it pursues. We report two cases of tubular adenoma with follicular and, in one case, additionally, sebaceous differentiation. The features in both cases indicated apocrine differentiation of the tubular component. One patient was a 60-year-old woman with a 1-year history of a solitary nodule on the scalp. The other patient was a 48-year-old woman with a solitary nodule of unknown duration located on the back. In both patients, the tumors were surgically removed. The patients were alive and well 2.5 and 2 years after surgery, respectively. The histologic features that both cases had in common included the combination of a tubular adenoma, foci of follicular differentiation, and areas of immature squamous metaplasia. In case 1, follicular differentiation was seen in the form of strands of basaloid cells surrounded by a stroma resembling the embryonic perifollicular sheath. Some aggregates of basaloid cells were juxtaposed with small collections of plump fibroblasts, imparting a resemblance to rudimentary ...Continue Reading

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Citations

Jan 24, 2008·The American Journal of Dermatopathology·Marina VazmitelDmitry V Kazakov
Apr 4, 2017·The American Journal of Surgical Pathology·Liubov KyrpychovaDmitry V Kazakov
Sep 13, 2011·The Journal of Dermatology·Daiki NakagomiShinji Shimada
Jun 3, 2021·International Journal of Molecular Sciences·Iga PłachtaPiotr Rutkowski
Apr 17, 2021·The American Journal of Dermatopathology·Juan Torre-CastroLuis Requena

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