Tubular Fibrous Scaffolds Functionalized with Tropoelastin as a Small-Diameter Vascular Graft.

Biomacromolecules
Sofia OliveiraNuno M Neves

Abstract

Cardiovascular disorders are a healthcare problem in today's society. The clinically available synthetic vascular grafts are thrombogenic and could induce intimal hyperplasia. Rapid endothelialization and matched mechanical properties are two major requirements to be considered when designing functional vascular grafts. Herein, an electrospun tubular fibrous (eTF) scaffold was biofunctionalized with tropoelastin at the luminal surface. The luminal surface functionalization was confirmed by an increase of the zeta potential and by the insertion of NH2 groups. Tropoelastin was immobilized via its -NH2 or -COOH groups at the activated or aminolysed eTF scaffolds, respectively, to study the effect of exposed functional groups on human endothelial cells (ECs) behavior. Tensile properties demonstrated that functionalized eTF scaffolds presented strength and stiffness within the range of those of native blood vessels. Tropoelastin immobilized on activated eTF scaffolds promoted higher metabolic activity and proliferation of ECs, whereas when immobilized on aminolysed eTF scaffolds, significantly higher protein synthesis was observed. These biofunctional eTF scaffolds are a promising small-diameter vascular graft that promote rapid end...Continue Reading

References

May 14, 1993·Science·R Langer, J P Vacanti
Dec 16, 1998·European Journal of Biochemistry·B Vrhovski, A S Weiss
Jun 28, 2000·Annals of Biomedical Engineering·D SeliktarR M Nerem
Dec 4, 2002·Circulation·Andrew D Michaels, Kanu Chatterjee
Apr 10, 2003·The Annals of Thoracic Surgery·David A VorpBartley P Griffith
Jul 17, 2004·Journal of Atherosclerosis and Thrombosis·Hiroshi WachiYoshiyuki Seyama
Aug 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Azita TajaddiniD Geoffrey Vince
May 13, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ruben Y KannanAlexander M Seifalian
Feb 24, 2006·Nature Medicine·Nicolas L'HeureuxTodd N McAllister
May 9, 2006·Colloids and Surfaces. B, Biointerfaces·Kaiyong CaiKlaus D Jandt
Nov 2, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sandip SarkarAlexander M Seifalian
Dec 22, 2007·Nanomedicine·Albino MartinsNuno M Neves
May 6, 2009·Expert Opinion on Drug Delivery·Suresh P Vyas, Bhuvaneshwar Vaidya
Jun 23, 2009·Acta Biomaterialia·Lorenzo SolettiDavid A Vorp
Feb 2, 2010·Thrombosis Research·Lisa M MaurerDeane F Mosher
Mar 2, 2010·Biomaterials·Young Min JuSang Jin Lee
Mar 30, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A DupreyR Berguer
Feb 4, 2011·Science Translational Medicine·Shannon L M DahlLaura E Niklason
Dec 27, 2011·Journal of Biomedical Nanotechnology·K T ShalumonR Jayakumar
Feb 7, 2012·Journal of Colloid and Interface Science·Daehwan ChoMargaret W Frey
Jul 13, 2012·Advanced Drug Delivery Reviews·Suzanne M MithieuxAnthony S Weiss
Apr 30, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Alireza KarimiShahab Faghihi
May 22, 2013·Nature Reviews. Cardiology·Dawit G SeifuDiego Mantovani
Jun 19, 2013·Journal of Biomedical Materials Research. Part a·Shawn RegisSankha Bhowmick
Dec 17, 2014·ACS Applied Materials & Interfaces·Ana B Faia-TorresNuno M Neves
Jun 5, 2015·Biomaterials·Nathan A HotalingCarl G Simon
Jul 24, 2015·PloS One·Meik NeufurthWerner E G Müller
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Y ElsayedP Tomlins
Dec 21, 2016·Biomacromolecules·Houman SavojiSophie Lerouge
Jan 23, 2017·Biomaterials·Shira LandauShulamit Levenberg

❮ Previous
Next ❯

Citations

Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Quanchao ZhangYizao Wan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.