PMID: 7091322Jun 1, 1982Paper

Tubular handling of Pi in young growing and adult rats

The American Journal of Physiology
J CaverzasioH Fleisch

Abstract

The tubular transport of inorganic phosphate (Pi) is controlled by a parathyroid hormone-independent mechanism that responds to variations in the Pi intake. This adaptation mechanism could also respond to growth-mediated variation in the utilization of Pi by the organism. In the present work we have determined the maximal net Pi reabsorption per volume of glomerular filtrate (max TRPi/ml GF) in the young growing (2-mo) and adult 8- to 9-mo) rats. Max TRP[i/ml GF was significantly lower in intact adult (1.44 +/- 0.06 mumol/ml) compared with intact young growing animals (2.22 +/- 0.12 mumol/ml GF). This difference was maintained after removal of the thyroparathyroid glands; adult, 2.89 +/- 0.25, young, 4.56 +/- 0.25 mumol/ml. It was not associated with a difference in the urinary excretion of cAMP, GFR, renal handling of sodium, plasma calcium, or acid-base status. Administration of growth hormone preparations to adult rats did not raise max TRPi/ml GF to the level observed in young intact animals. With regard to the tubular Pi adaptation to Pi restriction, lowering the phosphorus content in the diet from 0.8 to 0.2 g/100 g resulted in an attenuated and delayed enhancement in max TRPi/ml in adult as compared with the response obs...Continue Reading

Citations

Mar 5, 2004·American Journal of Physiology. Renal Physiology·C WodaS E Mulroney
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C WodaA Haramati

Related Concepts

Process of Absorption
Diet
Glomerular Filtration Rate
Renal Tubule Structure
Parathyroid Gland
Orthophosphate
August Rats
Thyroidectomy

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