PMID: 7091322Jun 1, 1982Paper

Tubular handling of Pi in young growing and adult rats

The American Journal of Physiology
J CaverzasioH Fleisch


The tubular transport of inorganic phosphate (Pi) is controlled by a parathyroid hormone-independent mechanism that responds to variations in the Pi intake. This adaptation mechanism could also respond to growth-mediated variation in the utilization of Pi by the organism. In the present work we have determined the maximal net Pi reabsorption per volume of glomerular filtrate (max TRPi/ml GF) in the young growing (2-mo) and adult 8- to 9-mo) rats. Max TRP[i/ml GF was significantly lower in intact adult (1.44 +/- 0.06 mumol/ml) compared with intact young growing animals (2.22 +/- 0.12 mumol/ml GF). This difference was maintained after removal of the thyroparathyroid glands; adult, 2.89 +/- 0.25, young, 4.56 +/- 0.25 mumol/ml. It was not associated with a difference in the urinary excretion of cAMP, GFR, renal handling of sodium, plasma calcium, or acid-base status. Administration of growth hormone preparations to adult rats did not raise max TRPi/ml GF to the level observed in young intact animals. With regard to the tubular Pi adaptation to Pi restriction, lowering the phosphorus content in the diet from 0.8 to 0.2 g/100 g resulted in an attenuated and delayed enhancement in max TRPi/ml in adult as compared with the response obs...Continue Reading


Mar 5, 2004·American Journal of Physiology. Renal Physiology·C WodaS E Mulroney
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C WodaA Haramati

Related Concepts

Process of Absorption
Glomerular Filtration Rate
Renal Tubule Structure
Parathyroid Gland
August Rats

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