Tubulin and actin interplay at the T cell and antigen-presenting cell interface.

Frontiers in Immunology
Noa B Martín-CófrecesFrancisco Sanchez-Madrid

Abstract

T cells reorganize their actin and tubulin-based cytoskeletons to provide a physical basis to the immune synapse. However, growing evidence shows that their roles on T cell activation are more dynamic than merely serving as tracks or scaffold for different molecules. The crosstalk between both skeletons may be important for the formation and movement of the lamella at the immunological synapse by increasing the adhesion of the T cell to the antigen-presenting cells (APC), thus favoring the transport of components toward the plasma membrane and in turn regulating the T-APC intercellular communication. Microtubules and F-actin appear to be essential for the transport of the different signaling microclusters along the membrane, therefore facilitating the propagation of the signal. Finally, they can also be important for regulating the endocytosis, recycling, and degradation of the T cell receptor signaling machinery, thus helping both to sustain the activated state and to switch it off.

Citations

Oct 15, 2013·Trends in Cell Biology·Noa Beatriz Martín-CófrecesFrancisco Sánchez-Madrid
Aug 26, 2015·The Journal of Cell Biology·Amanda Carroll-PortilloDiane S Lidke
Jan 3, 2013·Immunological Reviews·Cristina Gutiérrez-VázquezFrancisco Sánchez-Madrid
May 18, 2013·Biochimica Et Biophysica Acta·Sudha KumariMichael L Dustin
Dec 19, 2015·Nature Communications·Jan M HerterTanya N Mayadas
Jun 16, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luye HeHang Lu
Sep 24, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hironori UedaMark M Davis
Jun 19, 2018·Frontiers in Immunology·Noa Beatriz Martín-Cófreces, Francisco Sánchez-Madrid
Dec 5, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathrin ZimmermannAnnette Oxenius
Jun 4, 2020·Cells·Anton V Burakov, Elena S Nadezhdina
Jan 20, 2021·The Journal of Cell Biology·Amr H AllamSarah M Russell
Aug 24, 2017·Seminars in Cell & Developmental Biology·Arpita Upadhyaya
Mar 11, 2021·Molecular Biology of the Cell·Oane J GrosFlorian Berger

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Methods Mentioned

BETA
fluorescence microscopy
surface
chip
FRET
electron microscopy
fluorescence recovery after photobleaching
ubiquitination
transgenic
immunoprecipitation

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