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Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion

The Journal of Biological Chemistry

May 1, 2013

Patrick EjlerskovFrederik Vilhardt

Abstract

Aggregation of α-synuclein can be promoted by the tubulin polymerization-promoting protein/p25α, which we have used here as a tool to study the role of autophagy in the clearance of α-synuclein. In NGF-differentiated PC12 catecholaminergic nerve cells, we show that de novo expressed p25...read more

Mentioned in this Paper

Nerve Growth Factor gamma Subunit
Lysosome Assembly Pathway
Protein Digestion
Gene Knockdown Techniques
Microtubule-Associated Protein 3
Rab8 protein, rat
Cytoplasmic Vesicles
Rapamune
Secretory Pathway
Neurons
1
119
Paper Details
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Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion

The Journal of Biological Chemistry

May 1, 2013

Patrick EjlerskovFrederik Vilhardt

PMID: 23629650

DOI: 10.1074/jbc.m112.401174

Abstract

Aggregation of α-synuclein can be promoted by the tubulin polymerization-promoting protein/p25α, which we have used here as a tool to study the role of autophagy in the clearance of α-synuclein. In NGF-differentiated PC12 catecholaminergic nerve cells, we show that de novo expressed p25...read more

Mentioned in this Paper

Nerve Growth Factor gamma Subunit
Lysosome Assembly Pathway
Protein Digestion
Gene Knockdown Techniques
Microtubule-Associated Protein 3
Rab8 protein, rat
Cytoplasmic Vesicles
Rapamune
Secretory Pathway
Neurons
1
119

Similar Papers Found In These Feeds

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Paper Details
References
  • References65
  • Citations42
12345...
  • References65
  • Citations42
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