Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends

The Journal of Cell Biology
Leticia PerisDidier Job

Abstract

Tubulin-tyrosine ligase (TTL), the enzyme that catalyzes the addition of a C-terminal tyrosine residue to alpha-tubulin in the tubulin tyrosination cycle, is involved in tumor progression and has a vital role in neuronal organization. We show that in mammalian fibroblasts, cytoplasmic linker protein (CLIP) 170 and other microtubule plus-end tracking proteins comprising a cytoskeleton-associated protein glycine-rich (CAP-Gly) microtubule binding domain such as CLIP-115 and p150 Glued, localize to the ends of tyrosinated microtubules but not to the ends of detyrosinated microtubules. In vitro, the head domains of CLIP-170 and of p150 Glued bind more efficiently to tyrosinated microtubules than to detyrosinated polymers. In TTL-null fibroblasts, tubulin detyrosination and CAP-Gly protein mislocalization correlate with defects in both spindle positioning during mitosis and cell morphology during interphase. These results indicate that tubulin tyrosination regulates microtubule interactions with CAP-Gly microtubule plus-end tracking proteins and provide explanations for the involvement of TTL in tumor progression and in neuronal organization.

References

Jan 1, 1988·Molecular Neurobiology·H S BarraC E Argaraña
Mar 3, 1999·Cell·Franck PerezT E Kreis
Aug 28, 1999·The Journal of Biological Chemistry·J ScheelT E Kreis
Nov 1, 2000·Nature Cell Biology·N E FaulknerR B Vallee
Apr 10, 2002·Molecular and Cellular Biology·Frédéric M CoquelleOrly Reiner
Jul 12, 2002·Cell·Masaki FukataKozo Kaibuchi
Oct 4, 2002·Current Biology : CB·Gregg G Gundersen
Nov 26, 2002·The Journal of Cell Biology·Yulia KomarovaGary G Borisy
Jan 9, 2003·Current Opinion in Cell Biology·Niels Galjart, Franck Perez
Feb 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tarik F HaydarPasko Rakic
Feb 26, 2003·Cell·Thomas D Pollard, Gary G Borisy
May 14, 2003·Trends in Cell Biology·Pedro CarvalhoDavid Pellman
Mar 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·A C Badin-LarçonDidier Job
Jun 26, 2004·Cell Structure and Function·Jeannette Chloë BulinskiW Chang
Aug 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·J M VasilievE M Bonder
Sep 24, 2004·The Journal of Cell Biology·Gideon LansbergenAnna Akhmanova
Jan 6, 2005·The Journal of Cell Biology·Yuko Mimori-KiyosueAnna Akhmanova
Jan 22, 2005·Current Opinion in Cell Biology·Anna Akhmanova, Casper C Hoogenraad
Jan 28, 2005·Journal of Cell Science·Stephen M Huisman, Marisa Segal
May 11, 2005·The Journal of Cell Biology·Ayana T MooreLinda Wordeman
May 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Christian ErckJuergen Wehland
Sep 9, 2005·Molecular Biology of the Cell·Yulia KomarovaAnna Akhmanova
Sep 24, 2005·Nature Cell Biology·Manuel ThéryMichel Bornens
Dec 20, 2005·The EMBO Journal·Marvin E TanenbaumRené H Medema
Feb 14, 2006·Nature Cell Biology·Tara L Culver-HanlonStephen J King

Citations

Jul 1, 2009·Molecular Biotechnology·Richard H Wade
Mar 31, 2009·Molecular Neurobiology·Orly Reiner, Tamar Sapir
Apr 21, 2009·Nature Neuroscience·Yoshiyuki Konishi, Mitsutoshi Setou
Mar 7, 2008·Nature Reviews. Molecular Cell Biology·Anna Akhmanova, Michel O Steinmetz
Nov 17, 2011·Nature Reviews. Molecular Cell Biology·Carsten Janke, Jeannette Chloë Bulinski
Oct 25, 2011·Nature Structural & Molecular Biology·Agnieszka SzykAntonina Roll-Mecak
Sep 11, 2007·Nature Structural & Molecular Biology·Anke WeisbrichMichel O Steinmetz
Sep 26, 2009·The Journal of Biological Chemistry·Zhiqing C ZhuHolly V Goodson
Apr 8, 2010·The Journal of Biological Chemistry·Odile ValironDidier Job
Mar 3, 2009·The Journal of Biological Chemistry·Navin K VermaYuri Volkov
Feb 29, 2008·Molecular Biology of the Cell·Barbara BellettiGustavo Baldassarre
Sep 23, 2011·Molecular Biology of the Cell·Nikolas BalanisCathleen R Carlin
Jul 16, 2009·Neural Development·Katherine M KollinsGinger S Withers
Jul 10, 2012·Disease Models & Mechanisms·Coralie FassierJudith Melki
Oct 12, 2010·Journal of Cell Science·Dorota Wloga, Jacek Gaertig
Mar 2, 2010·Cell Structure and Function·Koji Ikegami, Mitsutoshi Setou
Dec 15, 2010·Cell Structure and Function·Nobuhisa IshidaKohji Takei
Mar 23, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Toshitaka AkisakaToshiya Takigawa
Mar 21, 2012·PloS One·Anouk BossonMarie-Jo Moutin
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Koji IkegamiMitsutoshi Setou
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Masaki MishimaToshio Hakoshima
Jul 3, 2013·Brain : a Journal of Neurology·Peter W Baas, Fridoon J Ahmad
Jul 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Qianmin WangNaoko Mizuno
Aug 20, 2014·The Journal of Cell Biology·Carsten Janke
Aug 21, 2013·Nature Chemical Biology·Jui-Hsia WengBon-Chu Chung
Jan 30, 2013·The Journal of Cell Biology·Andrea E ProtaMichel O Steinmetz
Sep 19, 2012·The Journal of Cell Biology·Laura Andrés-DelgadoMiguel A Alonso
Feb 20, 2008·The Journal of Cell Biology·Katharina A DragesteinNiels Galjart
Feb 4, 2010·Expert Review of Proteomics·Nicolas L YoungBenjamin A Garcia
Mar 18, 2009·The Journal of Cell Biology·Praveen KumarTorsten Wittmann
May 12, 2009·FEBS Letters·Koji Ikegami, Mitsutoshi Setou
Dec 24, 2008·The Journal of Cell Biology·Peter BielingThomas Surrey
Jul 1, 2009·The Journal of Cell Biology·Leticia PerisAnnie Andrieux
Sep 12, 2007·The Journal of Cell Biology·Neeraj SharmaJacek Gaertig
Jan 8, 2016·Molecular Biology of the Cell·Chrystelle AillaudMarie-Jo Moutin
Oct 16, 2015·Journal of Neurochemistry·Bryan A Killinger, Anna Moszczynska
Jul 4, 2012·Trends in Cell Biology·Praveen Kumar, Torsten Wittmann
May 19, 2012·Brain Research Bulletin·Benoit J Gentil, Laura Cooper
Nov 24, 2011·The International Journal of Biochemistry & Cell Biology·Hélène de ForgesFranck Perez
Dec 5, 2009·Current Opinion in Cell Biology·Kevin C Slep
Dec 25, 2009·Current Opinion in Cell Biology·Sandrine Etienne-Manneville
Nov 17, 2009·Journal of Molecular Biology·Kamlesh K GuptaHolly V Goodson
Jul 9, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Massimiliano BianchiCharles A Marsden
Oct 7, 2008·Trends in Biochemical Sciences·Michel O Steinmetz, Anna Akhmanova
Jan 30, 2008·Current Opinion in Cell Biology·Jennetta W HammondKristen J Verhey
Oct 10, 2007·Journal of Structural Biology·Roman I KoningA Mieke Mommaas
Mar 13, 2016·Cellular and Molecular Life Sciences : CMLS·Dieudonnée van de WilligeAnna Akhmanova
May 20, 2015·The Journal of Infectious Diseases·Sujittra ChaiyadetAlex Loukas
Jan 15, 2009·Journal of Neurochemistry·Elena RianoElena I Rugarli
Mar 3, 2009·Journal of Neurochemistry·Nobuyuki FukushimaToshifumi Tsujiuchi
Feb 18, 2010·International Journal of Cancer. Journal International Du Cancer·Christine WasylykBohdan Wasylyk
May 1, 2013·The FEBS Journal·Jennifer R FlemingWilliam N Hunter
Mar 24, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Janusz Rak, Abhijit Guha
Sep 26, 2012·British Journal of Pharmacology·Renaud PrudentLaurence Lafanechère
May 21, 2009·Glia·Nina G BauerCharles Ffrench-Constant
Oct 7, 2015·Frontiers in Cellular Neuroscience·Jyoti DubeySandhya P Koushika
Oct 9, 2008·Analytical Biochemistry·Pascal Verdier-PinardDiane Braguer
Oct 16, 2012·Journal of Ethnopharmacology·Dong-Feng WeiYing-Cun Bao
Oct 14, 2014·Seminars in Cell & Developmental Biology·Antonina Roll-Mecak
Feb 7, 2012·Molecular and Cellular Neurosciences·Xin-peng DunJohn K Chilton
May 20, 2014·Current Biology : CB·Jayne AikenJeffrey K Moore
Apr 25, 2015·Science·Marin BarisicHelder Maiato
Sep 5, 2013·Bioarchitecture·Kevin C Flynn
Jun 15, 2010·Trends in Neurosciences·Carsten Janke, Matthias Kneussel
Jul 14, 2010·Current Biology : CB·Niels Galjart
Sep 8, 2010·Molecular and Cellular Neurosciences·Lukas C Kapitein, Casper C Hoogenraad
Sep 25, 2007·Molecular Cell·Kevin C Slep, Ronald D Vale
Sep 22, 2012·Ageing Research Reviews·Ginger Tsz-Hin WongAndrew Chi-Kin Law
Nov 6, 2012·Current Biology : CB·Eszter K VladarJeffrey D Axelrod
May 18, 2013·Biochimica Et Biophysica Acta·David F Steele, David Fedida
Mar 31, 2009·Biochimica Et Biophysica Acta·J Wolff
Nov 10, 2009·American Journal of Human Genetics·Mohammad R AbdollahiEamonn Sheridan
Jan 4, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sybren L N MaasEsther N M Nolte-'t Hoen
Jun 28, 2016·Trends in Cell Biology·Marin Barisic, Helder Maiato
Jul 2, 2016·Brain Research Bulletin·Andrew J Matamoros, Peter W Baas
Jul 9, 2016·Progress in Neurobiology·Philippe De DeurwaerdèreMark J Millan
Feb 19, 2016·Cytoskeleton·Peter W BaasLanfranco Leo
Oct 8, 2016·Cell Adhesion & Migration·Mathijs VleugelMarileen Dogterom
Oct 21, 2016·Molecular and Cellular Neurosciences·Claudia CompagnucciEnrico Bertini
Apr 22, 2017·Small GTPases·Ruibai LuoPei-Wen Chen
Oct 27, 2017·International Journal of Molecular Sciences·Dorota WlogaHanna Fabczak
Oct 24, 2017·Journal of Developmental Biology·Jayne AikenJeffrey K Moore
Mar 23, 2017·Journal of Cell Science·Sudarshan GadadharCarsten Janke
Sep 8, 2017·The Journal of Cell Biology·Xiaoyi QuFrancesca Bartolini
Nov 1, 2018·Journal of Cellular Physiology·Veronica S SantanderCésar H Casale
Oct 9, 2015·Nature Communications·Jaclyn P KerrChristopher W Ward
Sep 1, 2017·Nature Reviews. Neuroscience·Jeffrey J NirschlErika L F Holzbaur
Mar 13, 2016·The EMBO Journal·Richard J McKenneyMinhajuddin Sirajuddin
Aug 11, 2019·Experimental Biology and Medicine·Matthew A CaporizzoBenjamin L Prosser
Nov 4, 2017·Science·Francis J McNally
Feb 29, 2020·Nature Reviews. Molecular Cell Biology·Carsten Janke, Maria M Magiera
Oct 16, 2015·Oncotarget·Laurence Froidevaux-KlipfelAnita Baillet
Dec 4, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alan HammerMaria Diakonova
Jun 7, 2020·Cells·Robert BeckerFelix B Engel
Jun 4, 2020·The Journal of Cell Biology·Hélène HenrieBéatrice Benoit
Sep 5, 2020·The Journal of Cell Biology·Shubham KesarwaniMinhajuddin Sirajuddin
Oct 1, 2019·Plant Signaling & Behavior·John Gardiner
Feb 22, 2017·Biology·Helder MaiatoMarin Barisic
Aug 8, 2019·Experimental Biology and Medicine·Caitlin M Logan, A Sue Menko
Jun 27, 2019·Nature Structural & Molecular Biology·Na WangHongda Huang
Aug 13, 2020·Cancers·Lauralie PeronneLaurence Lafanechère
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Filip BorysHanna Fabczak
May 9, 2013·The Journal of Biological Chemistry·Nikolas BalanisCathleen R Carlin
Sep 8, 2016·Cellular and Molecular Life Sciences : CMLS·Laura PellegriniKirsten Harvey
May 26, 2011·Médecine sciences : M/S·Marie-Jo MoutinCarsten Janke
Jul 15, 2011·Molecular and Cellular Biochemistry·Alexandre DeshiereOdile Filhol
Aug 24, 2019·International Journal of Molecular Sciences·Isabella BarbieroCharlotte Kilstrup-Nielsen
Apr 20, 2019·The European Journal of Neuroscience·Jun LiShigeo Okabe
Oct 12, 2018·International Journal of Molecular Sciences·Emmanuelle SoleilhacLaurence Lafanechère
Apr 30, 2016·The Journal of Biological Chemistry·Annapurna VemuAntonina Roll-Mecak
Apr 6, 2007·Cancer Research·Xavier FonroseLaurence Lafanechère
Jul 5, 2012·Cancer Research·Renaud PrudentLaurence Lafanechère
Oct 11, 2020·European Journal of Medicinal Chemistry·Shannon PecnardAbdallah Hamze

Related Concepts

Rsn protein, rat
CILP2 protein, human
Tubulin polyglutamylase
Fibroblasts
Interphase
Microtubule-Associated Protein 3
Microtubules
Meiotic Spindle Apparatus
Neoplasm Proteins
Nerve Tissue Proteins

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Christian ErckJuergen Wehland
Molecular Cell
Srinivas HonnappaMichel O Steinmetz
Nature Structural & Molecular Biology
Anke WeisbrichMichel O Steinmetz
Proceedings of the National Academy of Sciences of the United States of America
Masaki MishimaToshio Hakoshima
© 2021 Meta ULC. All rights reserved