Tuft cells: Distribution and connections with nerves and endocrine cells in mouse intestine

Experimental Cell Research
Xiaowen ChengE Ekblad

Abstract

Tuft cells are gastrointestinal (GI) sensory cells recognized by their characteristic shape and their microvilli "tuft". Aims of the present study were to elucidate their regional distribution and spatial connections with satiety associated endocrine cells and nerve fibers throughout the intestinal tract. C57BL/6 J mice were used in the experiments. The small intestine was divided into five segments, and the large intestine was kept undivided. The segments were coiled into "Swiss rolls". Numbers and topographic distribution of tuft cells and possible contacts with endocrine cells and nerve fibers were estimated in the different segments, using immunocytochemistry. Tuft cells were found throughout the intestines; the highest number was in proximal small intestine. Five percent of tuft cells were found in close proximity to cholecystokinin-immunoreactive (IR) endocrine cells and up to 10% were in contact with peptide YY- and glucagon-like peptide-1-IR endocrine cells. Sixty percent of tuft cells in the small intestine and 40% in the large intestine were found in contact with nerve fibers. Calcitonin gene-related peptide-IR fibers constituted one-third of the fiber-contacts in the small intestine and two-thirds in the large intest...Continue Reading

Citations

Feb 7, 2020·Physiological Reports·Luke A Schwerdtfeger, Stuart A Tobet
Jan 23, 2019·Cell and Tissue Research·Xiaowen ChengEva Ekblad
Aug 28, 2020·Frontiers in Immunology·Aduragbemi A FaniyiJohn J Worthington
Sep 15, 2020·Current Opinion in Gastroenterology·Yasutada AkibaJonathan D Kaunitz
Jun 15, 2021·Frontiers in Immunology·Pankaj AroraSusanne Brix

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