Tuft-to-capsule adhesions and their precursors: differences between the vascular and tubular poles of the human glomerulus

The Journal of Pathology
I W GibsonG B Lindop

Abstract

Human glomerular capillary tufts were removed by microdissection and scanning electron microscopy was used to examine the surface of the capillary tuft and the interior of its Bowman's capsule in order to identify connections between the tuft and capsule. Glomeruli were examined in histologically normal renal cortex from 12 kidneys removed for tumour and 12 renal allografts removed for end-stage rejection. In normal kidney, the glomerular tuft was connected to Bowman's capsule by single podocytes and their processes. At the vascular pole, these were predominantly associated with parietal podocytes which lined Bowman's capsule. At the tubular pole, occasional podocytic processes derived from the capillary tuft bridged Bowman's space and connected to Bowman's capsule where there were no parietal podocytes. These podocytic connections were also found in all rejected transplants, but in addition adhesions were identified which consisted of thicker connections between the tuft and capsule. At the vascular pole, tuft-to-capsule adhesions were found in all 12 kidneys; these were always associated with parietal podocytes. Tubular pole adhesions were identified in ten of the 12 transplants. They were associated with abnormal squamous ce...Continue Reading

References

Aug 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D S GardinerG B Lindop
Jan 1, 1992·Kidney International·I W GibsonG B Lindop
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·M NakajimaP Kincaid-Smith
Dec 1, 1988·The Journal of Pathology·S J Lee, A J Howie
Aug 1, 1981·Laboratory Investigation; a Journal of Technical Methods and Pathology·A Z Barabas, R Lannigan

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Citations

Nov 18, 2009·Journal of the American Society of Nephrology : JASN·Bart SmeetsMarcus J Moeller
Aug 18, 2005·Kidney International·Jean BariétyChristian Jacquot
Jan 24, 2009·The American Journal of Pathology·Daniela MacconiAndrea Remuzzi
May 12, 2012·The Biochemical Journal·Kristen K McCampbell, Rebecca A Wingert
Jul 28, 2016·European Journal of Pharmacology·Jennifer Eymael, Bart Smeets
Jul 15, 2015·Cell Transplantation·Maria Giovanna Francipane, Eric Lagasse
Aug 19, 2004·Transplantation·Brian J NankivellJeremy R Chapman
Jun 26, 2002·The Journal of Pathology·G B M LindopE P Cohen
Sep 11, 2010·Journal of the American Society of Nephrology : JASN·Laura Lasagni, Paola Romagnani
Sep 1, 2006·Journal of the American Society of Nephrology : JASN·Jean BarietyPatrick Bruneval
Sep 28, 2013·Journal of the American Society of Nephrology : JASN·Kevin SchulteMarcus J Moeller
Mar 4, 2000·The Journal of Pathology·A J HowieG W Lipkin
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Michel LE HirWilhelm Kriz

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