PMID: 9541242Apr 16, 1998Paper

Tuftelin--aspects of protein and gene structure

European Journal of Oral Sciences
D DeutschL W Fisher

Abstract

The acidic enamel protein tuftelin has now been cDNA cloned, sequenced and characterized in a number of vertebrate species. Recently, the bovine tuftelin gene structure was elucidated. Cloning of the human tuftelin gene and partial sequencing of a number of exons have also been achieved. Immunologically, the protein has been shown to be conserved throughout 550 million years of vertebrate evolution. The gene has been localized to the long arm of the autosomal chromosome 1. The mapping of the human tuftelin gene to a well-defined cytogenetic region could be important in understanding the etiology of autosomally inherited amelogenesis imperfecta, the most common hereditary disease of enamel. The present paper reviews the primary structure, mRNA/cDNA structure, and gene structure of tuftelin. It describes its immunolocalization at the light microscope level and at the ultrastructural level in both the ameloblast cells and in the extracellular enamel matrix. The timing of tuftelin expression and its possible roles in enamel formation are discussed.

Citations

Dec 5, 1998·Journal of Dental Research·M MacDougallC C Hu
Sep 16, 2005·The Journal of Clinical Pediatric Dentistry·Virginia Karapanou
Feb 3, 2007·Head & Face Medicine·Maria C L G SantosSergio R P Line
Jun 12, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Longjiang DingLinglin Zhang
Mar 30, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yoav LeiserDan Deutsch
Jul 26, 2005·Journal of Dental Research·R L SlaytonM L Marazita
Oct 22, 2005·Orthodontics & Craniofacial Research·M L Paine, M L Snead
May 11, 2005·Journal of Oral Science·María Angélica Torres-QuintanaNelson Lobos
Mar 25, 2019·Journal of Molecular Neuroscience : MN·Dekel ShiloPhilip Lazarovici
May 3, 2019·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Dekel ShiloDan Deutsch
Aug 12, 1999·Journal of Structural Biology·A G FinchamJ P Simmer

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