Tularemia Outbreaks and Common Vole (Microtus arvalis) Irruptive Population Dynamics in Northwestern Spain, 1997-2014

Vector Borne and Zoonotic Diseases
Juan José Luque-LarenaRaquel Escudero

Abstract

During the last decades, large tularemia outbreaks in humans have coincided in time and space with population outbreaks of common voles in northwestern Spain, leading us to hypothesize that this rodent species acts as a key spillover agent of Francisella tularensis in the region. Here, we evaluate for the first time a potential link between irruptive vole numbers and human tularemia outbreaks in Spain. We compiled vole abundance estimates obtained through live-trapping monitoring studies and official reports of human tularemia cases during the period 1997-2014. We confirm a significant positive association between yearly cases of tularemia infection in humans and vole abundance. High vole densities during outbreaks (up to 1000 voles/hectare) may therefore enhance disease transmission and spillover contamination in the environment. If this ecological link is further confirmed, the apparent multiannual cyclicity of common vole outbreaks might provide a basis for forecasting the risk of tularemia outbreaks in northwestern Spain.

References

Oct 5, 2002·Clinical Microbiology Reviews·Jill EllisRichard W Titball
Jul 31, 2012·Emerging Infectious Diseases·Miklós GyuraneczKároly Erdélyi
Apr 23, 2014·Emerging Infectious Diseases·Jaime Ariza-MiguelDavid Rodríguez-Lázaro

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Citations

Nov 18, 2017·PLoS Pathogens·Juan J Luque-LarenaXavier Lambin
Jun 8, 2018·PloS One·Juan RomaironeFrançois Mougeot
Jul 21, 2017·Emerging Infectious Diseases·Ruth Rodríguez-PastorJuan J Luque-Larena
Jun 12, 2019·Animals : an Open Access Journal From MDPI·Linas BalčiauskasVitalijus Stirkė
Jun 19, 2019·Emerging Infectious Diseases·Ruth Rodríguez-PastorJuan José Luque-Larena
Sep 8, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Ingmar JanseJoke van der Giessen
Apr 21, 2021·Integrative Zoology·Kyra JacoblinnertJens Jacob
Aug 7, 2021·Pathogens·Olga Mínguez-GonzálezElías-Fernando Rodríguez-Ferri
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Linas BalčiauskasVidmantas Remeikis
Aug 31, 2021·Frontiers in Veterinary Science·Silvia Herrero-CófrecesJuan José Luque-Larena

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