Tumor ablation using low-intensity ultrasound and sound excitable drug

Journal of Controlled Release : Official Journal of the Controlled Release Society
Ching-Hsuan TungBrian E O'Neill

Abstract

The cell membrane is a semi-fluid container that defines the boundary of cells, and provides an enclosed environment for vital biological processes. A sound excitable drug (SED) that is non-cytotoxic to cells is developed to disrupt the plasma membrane under gentle ultrasound insonation, 1MHz, 1W/cm2. The frequency and power density of insonation are within the physical therapy and medical imaging windows; thus the applied ultrasound is safe and not harmful to tissues. The insertion of SEDs into the plasma membrane is not toxic to cells; however, the intruding SEDs weaken the membrane's integrity. Under insonation, the ultrasound energy destabilized the SED disrupted membranes, resulting in membrane rupture and eventual cell death. In a xenograft breast tumor model, the SED alone or the ultrasound alone caused little adverse effects to tumor tissue, while the combined treatment triggered necrosis with a brief local insonation of 3min. The described sono-membrane rupture therapy could be a safe alternative to the currently used high-energy tissue ablation technology, which uses X-rays, gamma rays, electron beams, protons, or high-intensity focused ultrasound.

Citations

Dec 6, 2017·Drug Delivery and Translational Research·Ankit JainSanjay K Jain
Dec 19, 2020·Advanced Healthcare Materials·Hongzhi CaoXiaohe Tian
Jan 29, 2020·The Journal of Physical Chemistry Letters·Zhiyuan LiLihua Yang

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