Tumor and stromal-based contributions to head and neck squamous cell carcinoma invasion

Cancers
Steven M Markwell, Scott A Weed

Abstract

Head and neck squamous cell carcinoma (HNSCC) is typically diagnosed at advanced stages with evident loco-regional and/or distal metastases. The prevalence of metastatic lesions directly correlates with poor patient outcome, resulting in high patient mortality rates following metastatic development. The progression to metastatic disease requires changes not only in the carcinoma cells, but also in the surrounding stromal cells and tumor microenvironment. Within the microenvironment, acellular contributions from the surrounding extracellular matrix, along with contributions from various infiltrating immune cells, tumor associated fibroblasts, and endothelial cells facilitate the spread of tumor cells from the primary site to the rest of the body. Thus far, most attempts to limit metastatic spread through therapeutic intervention have failed to show patient benefit in clinic trails. The goal of this review is highlight the complexity of invasion-promoting interactions in the HNSCC tumor microenvironment, focusing on contributions from tumor and stromal cells in order to assist future therapeutic development and patient treatment.

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M D SchallerJ T Parsons
Oct 1, 1991·Molecular and Cellular Biology·H WuJ T Parsons
Jan 1, 1974·Cancer·J C ProbertM A Bagshaw
Feb 1, 1994·Journal of Cellular Physiology·T KellyW T Chen
Sep 25, 1998·The Journal of Biological Chemistry·C HuangX Zhan
Mar 26, 1999·Science·L C SandersP de Lanerolle
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·S LinderM Aepfelbacher
Apr 27, 2000·Virchows Archiv : an International Journal of Pathology·M SawatsubashiT Shin
Aug 18, 2000·Life Sciences·L F FungS W Tsao
Nov 25, 2000·Cancer Letters·D Y NohJ S Han
Feb 13, 2001·European Journal of Biochemistry·D Roymans, H Slegers
Aug 24, 2001·International Journal of Cancer. Journal International Du Cancer·C LissM W Lingen
Sep 4, 2001·Current Pharmaceutical Biotechnology·P M Steed, A H Chow
Jan 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Roberto BenelliAdriana Albini
May 7, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Claus W HeizmannBeat W Schäfer
Nov 14, 2002·International Journal of Oncology·Masaru Katoh
Jan 1, 2003·The American Journal of Pathology·Aida U JawhariJosephine C Adams
Feb 20, 2003·The Journal of Allergy and Clinical Immunology·Calman Prussin, Dean D Metcalfe
Mar 5, 2003·The Journal of Cell Biology·Datsun A HsiaDavid D Schlaepfer
Mar 5, 2003·The Journal of Biological Chemistry·Clare L AbramSara A Courtneidge
Mar 13, 2003·Molecular Biology of the Cell·Massimiliano BaldassarreRoberto Buccione
Mar 26, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Anak IamaroonSitthichai Wanachantararak
Apr 17, 2003·Molecular and Cellular Biology·Bong-Hyun AhnDo Sik Min
May 29, 2003·The Journal of Biological Chemistry·Sichuan XiJennifer Rubin Grandis
Jun 10, 2003·International Journal of Cancer. Journal International Du Cancer·Simon NinckChristel Herold-Mende
Jul 30, 2003·Cancer Metastasis Reviews·Veronica Gabarra-NieckoJill M Dunty
Aug 7, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Roland SedivySelma Hönigschnabl
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrizia ScapiniMarco A Cassatella
Apr 20, 2004·Experimental Cell Research·Laura SpinardiPier Carlo Marchisio
Apr 28, 2004·Current Opinion in Genetics & Development·David D Schlaepfer, Satyajit K Mitra
May 26, 2004·Biochemical Society Transactions·R Zaidel-BarB Geiger
Aug 31, 2004·The Journal of Biological Chemistry·Rebecca A StocktonMartin Alexander Schwartz

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Citations

Nov 7, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Shuichi Fujita, Tohru Ikeda
Nov 22, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Veronika Maria MetzlerJózsef Dudás
Sep 26, 2017·Connective Tissue Research·Gyudo LeeJeffrey J Fredberg
Aug 20, 2018·International Journal of Cancer. Journal International Du Cancer·Yang LiuXuerui Yang
Jan 18, 2018·Journal of Experimental & Clinical Cancer Research : CR·Nyanbol KuolKulmira Nurgali
Apr 4, 2019·Head & Neck·Marta TagliabueMohssen Ansarin
Jul 29, 2020·Journal of Cancer Research and Therapeutics·Shruti GuptaAnjali Narwal
May 28, 2017·Current Treatment Options in Oncology·Genrich Tolstonog, Christian Simon
Feb 23, 2021·Molecular Therapy Oncolytics·Yixiao QinYongyan Wu

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Methods Mentioned

BETA
nucleotide exchange
xenograft
surgical resection

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