PMID: 9440785Jan 24, 1998Paper

Tumor angiogenesis and p53 mutations: prognosis in head and neck cancer

Archives of Otolaryngology--head & Neck Surgery
P HegdeJ S Coon

Abstract

To assess how p53 gene mutations and microvessel density (MVD) may be used as prognostic markers for the study and management of head and neck squamous cell carcinomas and to investigate putative associations between p53 gene mutations and MVD and the relationship of these factors to tumor response to radiotherapy and/or chemotherapy at 6 weeks. Thirty-nine patients with squamous cell carcinoma of the head and neck, stages I to IV, who were examined at Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill, and its affiliated hospitals between 1993 and 1995 were monitored. Mutations in the p53 gene were identified by microdissection of tumor cells on frozen sections, followed by single-strand conformation polymorphism analysis of the products of polymerase chain reaction amplification of exons 5 to 9. The microvessels were immunostained with monoclonal antibodies to factor VIII and/or CD31. Microvessel counts were done by 2 investigators blinded to each other's counts and to the p53 gene status. Intratumoral or peritumoral microvascular "hot spots" were assessed and counts were done with an ocular grid in 3 x 200 fields of hot spots by each investigator. The mean of the highest values was considered. Statistical analysis was ...Continue Reading

Citations

Jul 21, 2005·Journal of the National Cancer Institute·Panayiotis A KyzasJohn P A Ioannidis
Aug 1, 1998·Otolaryngologic Clinics of North America·G J PetruzzelliS Yong
Apr 14, 2000·Clinical Otolaryngology and Allied Sciences·J GreenmanN D Stafford
Jun 26, 2001·Histopathology·K N NareshA M Borges
Nov 1, 2002·Cancer Control : Journal of the Moffitt Cancer Center·Lyon L Gleich, Frank N Salamone
May 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D SmithB G Haffty
Jun 5, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Heikki TeppoOlli-Pekka Alho
Feb 19, 2020·Fetal and Pediatric Pathology·Li LizhiXu Di
Feb 13, 2001·Oral Oncology·S Jefferies, W D Foulkes

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